Ovarian cancer in endometriosis: Clinical and molecular aspects

B. Lyttle, L. Bernardi, M. Ellen Pavone*

*Corresponding author for this work

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Endometriosis is a gynecological condition characterized by specific histological, molecular and clinical findings, that affects 5-10% of premenopausal women and has been implicated as a precursor for certain types of ovarian cancer. Clinical studies of endometriosis associated ovarian cancer (EAOC) suggest that patients present at a young age with a lower stage and grade of tumor, and are more likely to be premenopausal than women with other ovarian cancers. However, when overall survival is compared between these types of ovarian cancers, there is no difference noted. In addition, EAOC tumors are more likely to be found with a concurrent diagnosis of cancer, most commonly endometrial. Advances in technology, primarily the ability for whole genome sequencing, have led to the discovery of new mutations and further understanding of previously identified genes and pathways associated with EAOCs including PTEN, CTNNB1 (beta-catenin), KRAS, microsatellite instability and ARID1A. This paper will review the most recent clinical and molecular advances in the association of endometriosis and ovarian cancer.

Original languageEnglish (US)
Pages (from-to)155-164
Number of pages10
JournalMinerva Ginecologica
Volume66
Issue number2
StatePublished - Apr 2014

Keywords

  • Endometriosis
  • Gynecologic surgical procedures
  • Ovarian neoplasms

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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