Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice

Augusto Schneider; Scot J. Matkovich; Tatiana Saccon; Berta Victoria; Lina Spinel; Mitra Lavasani; Andrzej Bartke; Pawel Golusinski; Michal M. Masternak

doi:10.1016/j.mce.2016.09.019

Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice

Augusto Schneider^*, Scot J. Matkovich, Tatiana Saccon, Berta Victoria, Lina Spinel, Mitra Lavasani, Andrzej Bartke, Pawel Golusinski, Michal M. Masternak

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The aim of the current work was to evaluate the ovarian follicle reserve and the ovarian transcriptome in Ames dwarf (df/df) mice. The results suggest a delayed ovarian aging in df/df mice compared to normal (N) mice. Although a high number of genes were differentially expressed during aging of N mice, only a small fraction of these changed with aging in df/df mice. These alterations involved more than 500 categorized biological processes. The majority of these biological processes, including inflammatory/immune responses, were up-regulated with aging in N mice, while old df/df mice were characterized by down-regulation of these same processes in comparison to age matched N mice. However, biological processes related to DNA damage and repairing were commonly down-regulated with aging in both genotypes. In conclusion, delayed ovarian aging in long-living df/df mice was associated with reduced expression of genes related to the inflammatory and immune responses.

Original language	English (US)
Pages (from-to)	328-336
Number of pages	9
Journal	Molecular and Cellular Endocrinology
Volume	439
DOIs	https://doi.org/10.1016/j.mce.2016.09.019
State	Published - Jan 5 2017

Keywords

GH
IGF
Ovarian aging
Transcriptome
mRNA

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology

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10.1016/j.mce.2016.09.019

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title = "Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice",

abstract = "The aim of the current work was to evaluate the ovarian follicle reserve and the ovarian transcriptome in Ames dwarf (df/df) mice. The results suggest a delayed ovarian aging in df/df mice compared to normal (N) mice. Although a high number of genes were differentially expressed during aging of N mice, only a small fraction of these changed with aging in df/df mice. These alterations involved more than 500 categorized biological processes. The majority of these biological processes, including inflammatory/immune responses, were up-regulated with aging in N mice, while old df/df mice were characterized by down-regulation of these same processes in comparison to age matched N mice. However, biological processes related to DNA damage and repairing were commonly down-regulated with aging in both genotypes. In conclusion, delayed ovarian aging in long-living df/df mice was associated with reduced expression of genes related to the inflammatory and immune responses.",

keywords = "GH, IGF, Ovarian aging, Transcriptome, mRNA",

author = "Augusto Schneider and Matkovich, {Scot J.} and Tatiana Saccon and Berta Victoria and Lina Spinel and Mitra Lavasani and Andrzej Bartke and Pawel Golusinski and Masternak, {Michal M.}",

note = "Funding Information: This work was supported by Universidade Federal de Pelotas internal funds to AS; Washington University Department of Medicine internal funds to SJM; and National Institute on Aging of the National Institutes of Health (grants number R01AG032290 , P01AG031736 ). This work was also supported by Coordena{\c c}{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior (CAPES) and Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico (CNPq; grant number 455714/2014-2 ). Publisher Copyright: {\textcopyright} 2016 Elsevier Ireland Ltd",

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AU - Schneider, Augusto

AU - Matkovich, Scot J.

AU - Saccon, Tatiana

AU - Victoria, Berta

AU - Spinel, Lina

AU - Lavasani, Mitra

AU - Bartke, Andrzej

AU - Golusinski, Pawel

AU - Masternak, Michal M.

N1 - Funding Information: This work was supported by Universidade Federal de Pelotas internal funds to AS; Washington University Department of Medicine internal funds to SJM; and National Institute on Aging of the National Institutes of Health (grants number R01AG032290 , P01AG031736 ). This work was also supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; grant number 455714/2014-2 ). Publisher Copyright: © 2016 Elsevier Ireland Ltd

PY - 2017/1/5

Y1 - 2017/1/5

N2 - The aim of the current work was to evaluate the ovarian follicle reserve and the ovarian transcriptome in Ames dwarf (df/df) mice. The results suggest a delayed ovarian aging in df/df mice compared to normal (N) mice. Although a high number of genes were differentially expressed during aging of N mice, only a small fraction of these changed with aging in df/df mice. These alterations involved more than 500 categorized biological processes. The majority of these biological processes, including inflammatory/immune responses, were up-regulated with aging in N mice, while old df/df mice were characterized by down-regulation of these same processes in comparison to age matched N mice. However, biological processes related to DNA damage and repairing were commonly down-regulated with aging in both genotypes. In conclusion, delayed ovarian aging in long-living df/df mice was associated with reduced expression of genes related to the inflammatory and immune responses.

AB - The aim of the current work was to evaluate the ovarian follicle reserve and the ovarian transcriptome in Ames dwarf (df/df) mice. The results suggest a delayed ovarian aging in df/df mice compared to normal (N) mice. Although a high number of genes were differentially expressed during aging of N mice, only a small fraction of these changed with aging in df/df mice. These alterations involved more than 500 categorized biological processes. The majority of these biological processes, including inflammatory/immune responses, were up-regulated with aging in N mice, while old df/df mice were characterized by down-regulation of these same processes in comparison to age matched N mice. However, biological processes related to DNA damage and repairing were commonly down-regulated with aging in both genotypes. In conclusion, delayed ovarian aging in long-living df/df mice was associated with reduced expression of genes related to the inflammatory and immune responses.

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KW - IGF

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KW - Transcriptome

KW - mRNA

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Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice

Abstract

Keywords

ASJC Scopus subject areas

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