Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice

Augusto Schneider*, Scot J. Matkovich, Tatiana Saccon, Berta Victoria, Lina Spinel, Mitra Lavasani, Andrzej Bartke, Pawel Golusinski, Michal M. Masternak

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The aim of the current work was to evaluate the ovarian follicle reserve and the ovarian transcriptome in Ames dwarf (df/df) mice. The results suggest a delayed ovarian aging in df/df mice compared to normal (N) mice. Although a high number of genes were differentially expressed during aging of N mice, only a small fraction of these changed with aging in df/df mice. These alterations involved more than 500 categorized biological processes. The majority of these biological processes, including inflammatory/immune responses, were up-regulated with aging in N mice, while old df/df mice were characterized by down-regulation of these same processes in comparison to age matched N mice. However, biological processes related to DNA damage and repairing were commonly down-regulated with aging in both genotypes. In conclusion, delayed ovarian aging in long-living df/df mice was associated with reduced expression of genes related to the inflammatory and immune responses.

Original languageEnglish (US)
Pages (from-to)328-336
Number of pages9
JournalMolecular and Cellular Endocrinology
Volume439
DOIs
StatePublished - Jan 5 2017

Keywords

  • GH
  • IGF
  • Ovarian aging
  • Transcriptome
  • mRNA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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