Abstract
Objective: To study the overall and cause-specific HIV-related mortality in a cohort of HIV-seropositive subjects according to transmission category, race/ethnicity, sex and severity of immunosuppression. Design: A cohort of 1129 HIV-seropositive homo-/bisexual men, injecting drug users, and female partners of HIV-infected men were enrolled at six centers in San Francisco, Los Angeles, Chicago, Newark, Detroit and New York between 1 November 1988 and 1 November 1989. Subjects were evaluated every 6 months at least until 31 March 1994. Methods: The analyses of overall mortality for the subgroups of interest were performed with Kaplan-Meier plots and Cox proportional hazards models. Cause-specific analyses were performed on the primary cause of death using rates per 100 person-years of exposure. Results and Conclusions: Baseline severity of immunosuppression is the strongest predictor of mortality. There were no statistically significant differences in overall HIV-related mortality among transmission categories, race/ethnicity groups or sexes. There were differences, however, in cause-specific mortality among the different risk groups.
Original language | English (US) |
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Pages (from-to) | 1257-1264 |
Number of pages | 8 |
Journal | AIDS |
Volume | 10 |
Issue number | 11 |
DOIs | |
State | Published - 1996 |
Keywords
- AIDS
- Cause-specific mortality
- HIV
- HIV risk groups
- Mortality
- Survival analysis
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases