TY - JOUR
T1 - Overcoming the blood-brain barrier with an implantable ultrasound device
AU - Sonabend, Adam M.
AU - Stupp, Roger
N1 - Funding Information:
A.M. Sonabend is supported by the NIH Director's HRHR Program (5DP5OD021356-04), and Developmental funds from The Robert H. Lurie NCI Cancer Center Support Grant number P30CA060553. A.M. Sonabend and R. Stupp are supported by a Developmental Project Award from the Northwestern University SPORE for Translational Approaches to Brain Cancer (P50CA221747; principal investigator: Maciej Lesniak).
PY - 2019
Y1 - 2019
N2 - Ultrasound-based blood-brain barrier disruption enhances drug delivery. To bypass the human skull, an implantable ultrasound emitter was developed, and proven safe and feasible in a first-in-human trial. Next development steps aim for larger field of disruption, quantification of drug levels, use of various drugs, and ultimately a pivotal trial demonstrating improved outcome.
AB - Ultrasound-based blood-brain barrier disruption enhances drug delivery. To bypass the human skull, an implantable ultrasound emitter was developed, and proven safe and feasible in a first-in-human trial. Next development steps aim for larger field of disruption, quantification of drug levels, use of various drugs, and ultimately a pivotal trial demonstrating improved outcome.
UR - http://www.scopus.com/inward/record.url?scp=85068498873&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068498873&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-19-0932
DO - 10.1158/1078-0432.CCR-19-0932
M3 - Article
C2 - 31076548
AN - SCOPUS:85068498873
VL - 25
SP - 3750
EP - 3752
JO - Clinical Cancer Research
JF - Clinical Cancer Research
SN - 1078-0432
IS - 13
ER -