Overexpression of phospholipase C-γ1 in rat 3Y1 fibroblast cells leads to malignant transformation

Jong Soo Chang, Dong Young Noh, In Ae Park, Myung Jong Kim, Hebok Song, Sung Ho Ryu, Pann Ghill Suh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Phospholipase C-γ1 (PLC-γ1) mediates signals from various extracellular origins to evoke cellular events such as mitogenesis. Previously, we reported that PLC-γ1 was highly expressed in colorectal cancer and familial adenomatous polyposis, suggesting that PLC-γ1 might be oncogenic. In this study, we have established rat 3Y1 fibroblasts that overexpress whole PLC-γ1 and src homology 2 (SH2)-SH2-SH3 domain of PLC- γ1. These cells showed a transformed phenotype and were tumorigenic when transplanted into nude mice. These results indicate that overexpression of PLC-γ1 could transform rat fibroblasts, and the transformation is mediated by SH2-SH2-SH3 domain of PLC-γ1.

Original languageEnglish (US)
Pages (from-to)5465-5468
Number of pages4
JournalCancer Research
Volume57
Issue number24
StatePublished - Dec 15 1997

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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