Overexpression of vascular endothelial growth factor by MCF-7 breast cancer cells promotes estrogen-independent tumor growth in vivo

Ping Guo, Quan Fang, Huo Quan Tao, Christopher A. Schafer, Bruce M. Fenton, Ivan Ding, Bo Hu, Shi Yuan Cheng*

*Corresponding author for this work

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Alteration of the phenotype of breast cancers from estrogen-dependent to estrogen-independent growth often leads to the failure of antiestrogenic tumor therapies. We report that overexpression of vascular endothelial growth factor (VEGF) by estrogen-dependent MCF-7 breast cancer cells could abolish estrogen-dependent tumor growth in ovariectomized mice. In the absence of estrogen, MCF-7 VEGF-expressing tumors with increased vessel density showed growth kinetics similar to, or even greater than, that of parental MCF-7 tumors with estrogen supplementation. Overexpression of VEGF by MCF-7 cells or treatment on parental MCF-7 cells with recombinant VEGF also stimulated cell proliferation in culture. Our data suggest that VEGF stimulation of MCF-7 tumor angiogenesis and growth is mediated by both autocrine and paracrine mechanisms.

Original languageEnglish (US)
Pages (from-to)4684-4691
Number of pages8
JournalCancer Research
Volume63
Issue number15
StatePublished - Aug 1 2003

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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