Overview of Gastroesophageal Reflux Disease Treatments

Sabine Roman*, Peter J. Kahrilas

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Gastroesophageal reflux disease treatment modalities mirror the pathophysiology of the disease. As acid plays a key role in gastroesophageal reflux disease-associated mucosal lesions and symptoms, proton pump inhibitors are the dominant gastroesophageal reflux disease therapy, being the most potent inhibitors of acid secretion available. However, their effectiveness varies with the nature of the symptoms; they are more effective for heartburn than for regurgitation than for extraesophageal symptoms. Reflux inhibition using gamma-amino butyric acid B agonists may represent an alternative treatment for patients with typical gastroesophageal reflux disease symptoms that are insufficiently relieved by proton pump inhibitors. However, their effects are modest. Treating visceral hypersensitivity represents a potential alternative in cases of functional heartburn and chest pain. In refractory cases, the indications for laparoscopic fundoplication should be balanced against the risk of surgery. The best indications are for patients with esophagitis and proton pump inhibitor intolerance and/or persistent troublesome regurgitation.

Original languageEnglish (US)
Title of host publicationPractical Manual of Gastroesophageal Reflux Disease
PublisherJohn Wiley and Sons
Number of pages16
ISBN (Print)9780470656266
StatePublished - Jan 25 2013


  • GABAB agonists
  • Laparoscopic fundoplication
  • Proton pump inhibitors
  • Visceral hypersensitivity

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Overview of Gastroesophageal Reflux Disease Treatments'. Together they form a unique fingerprint.

Cite this