Abstract
Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, including ulcerative colitis and Crohn’s disease. Importantly, patients with IBD have a significantly increased risk for the development of colorectal carcinoma. Dietary inositol and its phosphates, as well as phospholipid derivatives, are well known to benefit human health in diverse pathologies including cancer prevention. Inosi-tol phosphates including InsP3, InsP6, and other pyrophosphates, play important roles in cellular metabolic and signal transduction pathways involved in the control of cell proliferation, differen-tiation, RNA export, DNA repair, energy transduction, ATP regeneration, and numerous others. In the review, we highlight the biologic function and health effects of inositol and its phosphates including the nature and sources of these molecules, potential nutritional deficiencies, their biologic metabolism and function, and finally, their role in the prevention of colitis-induced carcinogenesis.
Original language | English (US) |
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Article number | 31 |
Journal | Molecules |
Volume | 26 |
Issue number | 1 |
DOIs | |
State | Published - 2021 |
Funding
Funding: This research was funded by National Institutes of Health and National Institute of Diabetes and Digestive and Kidney Diseases, grant number CA172431, CA164041 and DK10776. Acknowledgments: This study was supported by NIH R01 DK10776, CA172431, and CA164041 to G.Y.Y.
Keywords
- Carcinogenesis
- Chemoprevention
- Colitis
- Inositol
- Inositol phosphates
ASJC Scopus subject areas
- Drug Discovery
- Analytical Chemistry
- Chemistry (miscellaneous)
- Molecular Medicine
- Physical and Theoretical Chemistry
- Pharmaceutical Science
- Organic Chemistry