Overview of neurobiology

Rajiv Tandon*, Morris B Goldman

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Schizophrenia is a brain disease. Indeed, at all levels (i.e., genes, molecules, cells, brain structures, circuits, physiology, and behavior), there is ample evidence of alterations in persons with schizophrenia. Yet virtually none of this information is of proven value to clinicians or researchers. Whereas a broad spectrum of neurobiological differences between individuals with and without schizophrenia has been demonstrated, two factors prevent their translation into clinically useful tools. First, neurobiological findings in schizophrenia are replicated with variable consistency, in part because of the significant heterogeneity of the disease and in part because of considerable differences in the methods employed. Thus, it is very likely that there are many schizophrenias with very different neurobiological underpinnings. Second, it is currently not known which of these neurobiological differences reflect a risk for developing the disease, which reflect active pathology, which reflect compensatory processes, and which reflect epiphenomena. This section focuses on neurobiological findings in schizophrenia, including those related to pathophysiology, genetics, and neuroimaging.

Original languageEnglish (US)
Title of host publicationSchizophrenia
Subtitle of host publicationRecent Advances in Diagnosis and Treatment
PublisherSpringer New York
Number of pages7
ISBN (Electronic)9781493906567
ISBN (Print)1493906550, 9781493906550
StatePublished - Feb 1 2014

ASJC Scopus subject areas

  • Medicine(all)


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