Overview of the cytoskeleton from an evolutionary perspective

Thomas D. Pollard*, Robert D. Goldman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Organisms in the three domains of life depend on protein polymers to form a cytoskeleton that helps to establish their shapes, maintain their mechanical integrity, divide, and, in many cases, move. Eukaryotes have the most complex cytoskeletons, comprising three cytoskeletal poly-mers—actin filaments, intermediate filaments, and microtubules—acted on by three families of motor proteins (myosin, kinesin, and dynein). Prokaryotes have polymers of proteins homologous to actin and tubulin but no motors, and a few bacteria have a protein related to intermediate filament proteins.

Original languageEnglish (US)
Article numbera030288
JournalCold Spring Harbor Perspectives in Biology
Issue number7
StatePublished - Jul 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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