Oxidants painting the cysteine chapel: Redox regulation of PTPs

Dong Xu*, Ilsa I. Rovira, Toren Finkel

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

128 Scopus citations

Abstract

Growth factors and cytokines appear to stimulate the intracellular production of reactive oxygen species (ROS). Evidence suggests that this alteration in the cellular redox state is essential for downstream signaling, but the precise mechanism has remained elusive. A new study now demonstrates that ligand-stimulated intracellular hydrogen peroxide can specifically and reversibly regulate the activity of protein tyrosine phosphatases.

Original languageEnglish (US)
Pages (from-to)251-252
Number of pages2
JournalDevelopmental Cell
Volume2
Issue number3
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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