Oxidants painting the cysteine chapel: Redox regulation of PTPs

Dong Xu; Ilsa I. Rovira; Toren Finkel

doi:10.1016/S1534-5807(02)00132-6

Oxidants painting the cysteine chapel: Redox regulation of PTPs

Dong Xu^*, Ilsa I. Rovira, Toren Finkel

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Review article › peer-review

137 Scopus citations

Abstract

Growth factors and cytokines appear to stimulate the intracellular production of reactive oxygen species (ROS). Evidence suggests that this alteration in the cellular redox state is essential for downstream signaling, but the precise mechanism has remained elusive. A new study now demonstrates that ligand-stimulated intracellular hydrogen peroxide can specifically and reversibly regulate the activity of protein tyrosine phosphatases.

Original language	English (US)
Pages (from-to)	251-252
Number of pages	2
Journal	Developmental Cell
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/S1534-5807(02)00132-6
State	Published - 2002

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/S1534-5807(02)00132-6

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title = "Oxidants painting the cysteine chapel: Redox regulation of PTPs",

abstract = "Growth factors and cytokines appear to stimulate the intracellular production of reactive oxygen species (ROS). Evidence suggests that this alteration in the cellular redox state is essential for downstream signaling, but the precise mechanism has remained elusive. A new study now demonstrates that ligand-stimulated intracellular hydrogen peroxide can specifically and reversibly regulate the activity of protein tyrosine phosphatases.",

author = "Dong Xu and Rovira, {Ilsa I.} and Toren Finkel",

year = "2002",

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TY - JOUR

T1 - Oxidants painting the cysteine chapel

T2 - Redox regulation of PTPs

AU - Xu, Dong

AU - Rovira, Ilsa I.

AU - Finkel, Toren

PY - 2002

Y1 - 2002

N2 - Growth factors and cytokines appear to stimulate the intracellular production of reactive oxygen species (ROS). Evidence suggests that this alteration in the cellular redox state is essential for downstream signaling, but the precise mechanism has remained elusive. A new study now demonstrates that ligand-stimulated intracellular hydrogen peroxide can specifically and reversibly regulate the activity of protein tyrosine phosphatases.

AB - Growth factors and cytokines appear to stimulate the intracellular production of reactive oxygen species (ROS). Evidence suggests that this alteration in the cellular redox state is essential for downstream signaling, but the precise mechanism has remained elusive. A new study now demonstrates that ligand-stimulated intracellular hydrogen peroxide can specifically and reversibly regulate the activity of protein tyrosine phosphatases.

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U2 - 10.1016/S1534-5807(02)00132-6

DO - 10.1016/S1534-5807(02)00132-6

M3 - Review article

C2 - 11879627

AN - SCOPUS:0036193746

SN - 1534-5807

VL - 2

SP - 251

EP - 252

JO - Developmental Cell

JF - Developmental Cell

IS - 3

ER -

Oxidants painting the cysteine chapel: Redox regulation of PTPs

Abstract

ASJC Scopus subject areas

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