Oxidative carbon-carbon bond formation via silyl bis-enol ethers: Controlled cross-coupling for the synthesis of quaternary centers

Michael D. Clift, Carla N. Taylor, Regan James Thomson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

(Chemical Equation Presented) Unsymmetrical silyl bis-enol ethers have been developed as effective substrates for synthesizing quaternary centers from tetralone derivatives through oxidative carbon-carbon bond formation. The derived products are shown to be highly versatile intermediates that may be used to generate diverse structures such as cyclopentenones, 2H-pyrroles, and spirocyclic pyrrolidines.

Original languageEnglish (US)
Pages (from-to)4667-4669
Number of pages3
JournalOrganic Letters
Volume9
Issue number22
DOIs
StatePublished - Oct 25 2007

ASJC Scopus subject areas

  • Molecular Medicine

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