Oxidative carbon-carbon bond formation via silyl bis-enol ethers: Controlled cross-coupling for the synthesis of quaternary centers

(Chemical Equation Presented) Unsymmetrical silyl bis-enol ethers have been developed as effective substrates for synthesizing quaternary centers from tetralone derivatives through oxidative carbon-carbon bond formation. The derived products are shown to be highly versatile intermediates that may be used to generate diverse structures such as cyclopentenones, 2H-pyrroles, and spirocyclic pyrrolidines.