Oxidative damage of DNA induced by x-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction

Wei Gao, Jin Xiao Liang, Shuai Liu, Chang Liu, Xiao Fang Liu, Xiao Qi Wang, Qiu Yan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

X irradiation may lead to female infertility and the mechanism is still not clear. After X irradiation exposure, significantly morphological changes and functional decline in endometrial epithelial cells were observed. The mitochondrial and lysosomal dysfunction and oxidative DNA damage were noticed after X irradiation. In addition, pretreatment with NAC, NH4Cl or Pep A reduced the X irradiation induced damages. These studies demonstrate that the oxidative DNA damage which involved dysfunctional lysosomal and mitochondrial contribute to X irradiation-induced impaired receptive state of uterine endometrium and proper protective reagents can be helpful in improving endometrial function.

Original languageEnglish (US)
Pages (from-to)3401-3410
Number of pages10
JournalInternational Journal of Clinical and Experimental Medicine
Volume8
Issue number3
StatePublished - May 30 2015

Keywords

  • DNA damage
  • Endometrial receptivity
  • Lysosomal membrane instability
  • Mitochondrial dysfunction
  • Oxidative stress
  • X irradiation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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