Oxidative damage of DNA induced by x-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction

Wei Gao; Jin Xiao Liang; Shuai Liu; Chang Liu; Xiao Fang Liu; Xiao Qi Wang; Qiu Yan

Oxidative damage of DNA induced by x-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction

Wei Gao, Jin Xiao Liang, Shuai Liu, Chang Liu, Xiao Fang Liu, Xiao Qi Wang, Qiu Yan^*

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

X irradiation may lead to female infertility and the mechanism is still not clear. After X irradiation exposure, significantly morphological changes and functional decline in endometrial epithelial cells were observed. The mitochondrial and lysosomal dysfunction and oxidative DNA damage were noticed after X irradiation. In addition, pretreatment with NAC, NH₄Cl or Pep A reduced the X irradiation induced damages. These studies demonstrate that the oxidative DNA damage which involved dysfunctional lysosomal and mitochondrial contribute to X irradiation-induced impaired receptive state of uterine endometrium and proper protective reagents can be helpful in improving endometrial function.

Original language	English (US)
Pages (from-to)	3401-3410
Number of pages	10
Journal	International Journal of Clinical and Experimental Medicine
Volume	8
Issue number	3
State	Published - May 30 2015

Keywords

DNA damage
Endometrial receptivity
Lysosomal membrane instability
Mitochondrial dysfunction
Oxidative stress
X irradiation

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Oxidative damage of DNA induced by x-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction",

abstract = "X irradiation may lead to female infertility and the mechanism is still not clear. After X irradiation exposure, significantly morphological changes and functional decline in endometrial epithelial cells were observed. The mitochondrial and lysosomal dysfunction and oxidative DNA damage were noticed after X irradiation. In addition, pretreatment with NAC, NH4Cl or Pep A reduced the X irradiation induced damages. These studies demonstrate that the oxidative DNA damage which involved dysfunctional lysosomal and mitochondrial contribute to X irradiation-induced impaired receptive state of uterine endometrium and proper protective reagents can be helpful in improving endometrial function.",

keywords = "DNA damage, Endometrial receptivity, Lysosomal membrane instability, Mitochondrial dysfunction, Oxidative stress, X irradiation",

author = "Wei Gao and Liang, {Jin Xiao} and Shuai Liu and Chang Liu and Liu, {Xiao Fang} and Wang, {Xiao Qi} and Qiu Yan",

year = "2015",

month = may,

day = "30",

language = "English (US)",

volume = "8",

pages = "3401--3410",

journal = "International Journal of Clinical and Experimental Medicine",

issn = "1940-5901",

publisher = "e-Century Publishing Corporation",

number = "3",

}

Oxidative damage of DNA induced by x-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction. / Gao, Wei; Liang, Jin Xiao; Liu, Shuai; Liu, Chang; Liu, Xiao Fang; Wang, Xiao Qi; Yan, Qiu.

In: International Journal of Clinical and Experimental Medicine, Vol. 8, No. 3, 30.05.2015, p. 3401-3410.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Oxidative damage of DNA induced by x-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction

AU - Gao, Wei

AU - Liang, Jin Xiao

AU - Liu, Shuai

AU - Liu, Chang

AU - Liu, Xiao Fang

AU - Wang, Xiao Qi

AU - Yan, Qiu

PY - 2015/5/30

Y1 - 2015/5/30

N2 - X irradiation may lead to female infertility and the mechanism is still not clear. After X irradiation exposure, significantly morphological changes and functional decline in endometrial epithelial cells were observed. The mitochondrial and lysosomal dysfunction and oxidative DNA damage were noticed after X irradiation. In addition, pretreatment with NAC, NH4Cl or Pep A reduced the X irradiation induced damages. These studies demonstrate that the oxidative DNA damage which involved dysfunctional lysosomal and mitochondrial contribute to X irradiation-induced impaired receptive state of uterine endometrium and proper protective reagents can be helpful in improving endometrial function.

AB - X irradiation may lead to female infertility and the mechanism is still not clear. After X irradiation exposure, significantly morphological changes and functional decline in endometrial epithelial cells were observed. The mitochondrial and lysosomal dysfunction and oxidative DNA damage were noticed after X irradiation. In addition, pretreatment with NAC, NH4Cl or Pep A reduced the X irradiation induced damages. These studies demonstrate that the oxidative DNA damage which involved dysfunctional lysosomal and mitochondrial contribute to X irradiation-induced impaired receptive state of uterine endometrium and proper protective reagents can be helpful in improving endometrial function.

KW - DNA damage

KW - Endometrial receptivity

KW - Lysosomal membrane instability

KW - Mitochondrial dysfunction

KW - Oxidative stress

KW - X irradiation

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Oxidative damage of DNA induced by x-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction

Abstract

Keywords

ASJC Scopus subject areas

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