Abstract
X irradiation may lead to female infertility and the mechanism is still not clear. After X irradiation exposure, significantly morphological changes and functional decline in endometrial epithelial cells were observed. The mitochondrial and lysosomal dysfunction and oxidative DNA damage were noticed after X irradiation. In addition, pretreatment with NAC, NH4Cl or Pep A reduced the X irradiation induced damages. These studies demonstrate that the oxidative DNA damage which involved dysfunctional lysosomal and mitochondrial contribute to X irradiation-induced impaired receptive state of uterine endometrium and proper protective reagents can be helpful in improving endometrial function.
Original language | English (US) |
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Pages (from-to) | 3401-3410 |
Number of pages | 10 |
Journal | International Journal of Clinical and Experimental Medicine |
Volume | 8 |
Issue number | 3 |
State | Published - May 30 2015 |
Keywords
- DNA damage
- Endometrial receptivity
- Lysosomal membrane instability
- Mitochondrial dysfunction
- Oxidative stress
- X irradiation
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology