Oxidative stress and its implications for future treatments and management of alzheimer disease

Timothy A. Clark, Hyun Pil Lee, Raj K. Rolston, Xiongwei Zhu, Michael W. Marlatt, Rudy J. Castellani, Akihiko Nunomura, Gemma Casadesus, Mark A. Smith, Hyoung gon Lee, George Perry*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Oxidative imbalance is one of the earliest manifestations of Alzheimer disease (AD) actually preceding the classic pathology of amyloid β deposits and neurofibrillary tangles. Clinical trials examining antioxidant modulation by a number of global interventions show efficacy, while simple supplementation has limited benefit suggesting complexity of multiple contributing factors. In this review, we highlight new insights regarding novel approaches to understanding and treating AD based on holistic views of oxidative balance including diet.

Original languageEnglish (US)
Pages (from-to)225-227
Number of pages3
JournalInternational Journal of Biomedical Science
Volume6
Issue number3
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • Apolipoprotein E
  • Copper
  • Free radical
  • Iron
  • Lipid peroxidation
  • Oxygen species
  • Reactive
  • Vitamin E

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'Oxidative stress and its implications for future treatments and management of alzheimer disease'. Together they form a unique fingerprint.

Cite this