Oxime Ligation on the Surface of Mesoporous Silica Nanoparticles

Daniel P. Ferris; Paul R. McGonigal; Leah S. Witus; Takatoshi Kawaji; Mohammed M. Algaradah; Ahmed R. Alnajadah; Majed S. Nassar; J. Fraser Stoddart

doi:10.1021/acs.orglett.5b00740

Oxime Ligation on the Surface of Mesoporous Silica Nanoparticles

Daniel P. Ferris, Paul R. McGonigal, Leah S. Witus, Takatoshi Kawaji, Mohammed M. Algaradah, Ahmed R. Alnajadah, Majed S. Nassar, J. Fraser Stoddart^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

(Chemical Equation Presented). A versatile surface-functionalization strategy applicable to mesoporous silica nanoparticles, which could potentially serve as drug delivery vehicles, is described that makes use of alkoxyamine tethers on the surface of the nanoparticles. A wide variety of carbonyl compounds can be attached readily to these tethers under the mild conditions of oxime ether formation, simply by incubating the chemically modified mesoporous silica nanoparticles with aldehydes or ketones in water.

Original language	English (US)
Pages (from-to)	2146-2149
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	9
DOIs	https://doi.org/10.1021/acs.orglett.5b00740
State	Published - May 1 2015

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ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.5b00740

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title = "Oxime Ligation on the Surface of Mesoporous Silica Nanoparticles",

abstract = "(Chemical Equation Presented). A versatile surface-functionalization strategy applicable to mesoporous silica nanoparticles, which could potentially serve as drug delivery vehicles, is described that makes use of alkoxyamine tethers on the surface of the nanoparticles. A wide variety of carbonyl compounds can be attached readily to these tethers under the mild conditions of oxime ether formation, simply by incubating the chemically modified mesoporous silica nanoparticles with aldehydes or ketones in water.",

author = "Ferris, {Daniel P.} and McGonigal, {Paul R.} and Witus, {Leah S.} and Takatoshi Kawaji and Algaradah, {Mohammed M.} and Alnajadah, {Ahmed R.} and Nassar, {Majed S.} and Stoddart, {J. Fraser}",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

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doi = "10.1021/acs.orglett.5b00740",

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AU - Ferris, Daniel P.

AU - McGonigal, Paul R.

AU - Witus, Leah S.

AU - Kawaji, Takatoshi

AU - Algaradah, Mohammed M.

AU - Alnajadah, Ahmed R.

AU - Nassar, Majed S.

AU - Stoddart, J. Fraser

PY - 2015/5/1

Y1 - 2015/5/1

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AB - (Chemical Equation Presented). A versatile surface-functionalization strategy applicable to mesoporous silica nanoparticles, which could potentially serve as drug delivery vehicles, is described that makes use of alkoxyamine tethers on the surface of the nanoparticles. A wide variety of carbonyl compounds can be attached readily to these tethers under the mild conditions of oxime ether formation, simply by incubating the chemically modified mesoporous silica nanoparticles with aldehydes or ketones in water.

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JO - Organic Letters

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ER -

Oxime Ligation on the Surface of Mesoporous Silica Nanoparticles

Abstract

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