Oxygen cost of chloride transport in perfused rectal gland of Squalus acanthias

Patricio Silva*, Jeffrey S. Stoff, Richard J. Solomon, Robert Rosa, Arthur Stevens, Jonathan Epstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

In the stimulated state, with glucose as substrate, oxygen uptake by the isolated perfused rectal gland is directly related to the rate of chloride secretion. Lactate production is negligible under aerobic conditions in the stimulated gland. A stoichiometric relationship exists between chloride transport and oxygen consumption, with a Cl/O 2 ratio of about 30:1, resembling that reported for sodium in mammalian kidneys. This ratio remains constant under varying degrees and modes of stimulation. The ratio does not change when the gland is induced to secrete chloride against varying electrochemical gradients by altering the concentration of urea in the perfusate.

Original languageEnglish (US)
Pages (from-to)215-221
Number of pages7
JournalThe Journal of Membrane Biology
Volume53
Issue number3
DOIs
StatePublished - Oct 1 1980

ASJC Scopus subject areas

  • Biophysics
  • Physiology
  • Cell Biology

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