Oxygen cost of chloride transport in perfused rectal gland of Squalus acanthias

Patricio Silva; Jeffrey S. Stoff; Richard J. Solomon; Robert Rosa; Arthur Stevens; Jonathan Epstein

doi:10.1007/BF01868827

Oxygen cost of chloride transport in perfused rectal gland of Squalus acanthias

Patricio Silva^*, Jeffrey S. Stoff, Richard J. Solomon, Robert Rosa, Arthur Stevens, Jonathan Epstein

^*Corresponding author for this work

Medicine, Nephrology Division

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

In the stimulated state, with glucose as substrate, oxygen uptake by the isolated perfused rectal gland is directly related to the rate of chloride secretion. Lactate production is negligible under aerobic conditions in the stimulated gland. A stoichiometric relationship exists between chloride transport and oxygen consumption, with a Cl/O ₂ ratio of about 30:1, resembling that reported for sodium in mammalian kidneys. This ratio remains constant under varying degrees and modes of stimulation. The ratio does not change when the gland is induced to secrete chloride against varying electrochemical gradients by altering the concentration of urea in the perfusate.

Original language	English (US)
Pages (from-to)	215-221
Number of pages	7
Journal	The Journal of Membrane Biology
Volume	53
Issue number	3
DOIs	https://doi.org/10.1007/BF01868827
State	Published - Oct 1 1980

ASJC Scopus subject areas

Biophysics
Physiology
Cell Biology

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title = "Oxygen cost of chloride transport in perfused rectal gland of Squalus acanthias",

abstract = " In the stimulated state, with glucose as substrate, oxygen uptake by the isolated perfused rectal gland is directly related to the rate of chloride secretion. Lactate production is negligible under aerobic conditions in the stimulated gland. A stoichiometric relationship exists between chloride transport and oxygen consumption, with a Cl/O 2 ratio of about 30:1, resembling that reported for sodium in mammalian kidneys. This ratio remains constant under varying degrees and modes of stimulation. The ratio does not change when the gland is induced to secrete chloride against varying electrochemical gradients by altering the concentration of urea in the perfusate.",

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AU - Silva, Patricio

AU - Stoff, Jeffrey S.

AU - Solomon, Richard J.

AU - Rosa, Robert

AU - Stevens, Arthur

AU - Epstein, Jonathan

PY - 1980/10/1

Y1 - 1980/10/1

N2 - In the stimulated state, with glucose as substrate, oxygen uptake by the isolated perfused rectal gland is directly related to the rate of chloride secretion. Lactate production is negligible under aerobic conditions in the stimulated gland. A stoichiometric relationship exists between chloride transport and oxygen consumption, with a Cl/O 2 ratio of about 30:1, resembling that reported for sodium in mammalian kidneys. This ratio remains constant under varying degrees and modes of stimulation. The ratio does not change when the gland is induced to secrete chloride against varying electrochemical gradients by altering the concentration of urea in the perfusate.

AB - In the stimulated state, with glucose as substrate, oxygen uptake by the isolated perfused rectal gland is directly related to the rate of chloride secretion. Lactate production is negligible under aerobic conditions in the stimulated gland. A stoichiometric relationship exists between chloride transport and oxygen consumption, with a Cl/O 2 ratio of about 30:1, resembling that reported for sodium in mammalian kidneys. This ratio remains constant under varying degrees and modes of stimulation. The ratio does not change when the gland is induced to secrete chloride against varying electrochemical gradients by altering the concentration of urea in the perfusate.

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Oxygen cost of chloride transport in perfused rectal gland of Squalus acanthias

Abstract

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