Oxygen deprivation induced cell death: An update

J. K. Brunelle, Navdeep Chandel*

*Corresponding author for this work

Research output: Contribution to journalShort survey

130 Scopus citations

Abstract

Mammalian cells have multiple responses to low or zero oxygen concentrations. In the complete absence of oxygen, cells undergo cell death through apoptosis, and not necrosis. Apoptotic signaling during oxygen deprivation occurs through the release of cytochrome c and apaf-1 mediated caspase-9 activation. The upstream regulators of cytochrome c release are the Bcl-2 family members. Pro-apoptotic Bcl-2 family members such as bax or bak are clearly required to initiate cytochrome c/apaf-1/caspase-9 mediated cell death during oxygen deprivation. Here we review what is currently known oxygen deprivation induced cell death and speculate about initiating mechanisms resulting in the activation of pro-apoptotic Bcl-2 family members.

Original languageEnglish (US)
Pages (from-to)475-482
Number of pages8
JournalApoptosis
Volume7
Issue number6
DOIs
StatePublished - Dec 1 2002

Keywords

  • Anoxia
  • Bax
  • Bcl-2
  • Hypoxia
  • Mitochondria

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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