P300 amplitude and topography in an autobiographical oddball paradigm involving simulated amnesia

Antoinette R. Miller, J. Peter Rosenfeld*, Matthew Soskins, Marianne Jhee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The P300 component of the event-related potential was recorded during two blocks of an autobiographical oddball task. All participants performed honestly during the first block (Phone), i.e., the oddball stimuli were phone numbers. During the second block (Birthday), in which the oddball stimuli were participants' birthdays, a Truth group (N = 13) performed honestly and a Malinger group (N = 14) simulated amnesia. Amnesia simulation significantly reduced P300 amplitudes, both between groups and within the Malinger group (Phone vs. Birthday), possibly because of an increase in task difficulty in the Malinger condition. Analysis of scaled amplitudes also a trend for a feigning-related alteration in P300 topography. Bootstrapping of peak-to-peak amplitudes detected significantly more (93%) Malinger individuals than bootstrapping of baseline-to-peak ampli-tudes (64%). Bootstrapping also provided evidence of a feigning-related amplitude difference between oddball stimuli (i.e., Phone > Birthday) in 71 % of Malinger group individuals. In this comparison, the peak-to-peak measure also performed significantly better in intraindividual diagnostics.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalJournal of Psychophysiology
Volume16
Issue number1
DOIs
StatePublished - Jan 1 2002

Keywords

  • Amnesia
  • Amplitude
  • Autobiographical oddball
  • Feigning
  • Malingering
  • P300
  • Topography

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Physiology

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