p38δ mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis

Tatiana Efimova*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

The p38δ mitogen-activated protein kinase (MAPK) is abundantly expressed in a wide array of tissues where it is likely to have specific functions. This review aims to highlight recent new insights into the biological roles of this relatively less studied p38 isoform. We focus on function of p38δ in regulating of epidermal keratinocyte differentiation, apoptosis and skin tumor development.

Original languageEnglish (US)
Pages (from-to)498-505
Number of pages8
JournalCell Cycle
Volume9
Issue number3
DOIs
StatePublished - Feb 1 2010

Keywords

  • Epidermis
  • Keratinocyte
  • Knockout mice
  • Multistage chemical skin carcinogenesis
  • p38δ signaling

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Developmental Biology

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