p38δ mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis

Tatiana Efimova

doi:10.4161/cc.9.3.10541

p38δ mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis

Tatiana Efimova^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

The p38δ mitogen-activated protein kinase (MAPK) is abundantly expressed in a wide array of tissues where it is likely to have specific functions. This review aims to highlight recent new insights into the biological roles of this relatively less studied p38 isoform. We focus on function of p38δ in regulating of epidermal keratinocyte differentiation, apoptosis and skin tumor development.

Original language	English (US)
Pages (from-to)	498-505
Number of pages	8
Journal	Cell Cycle
Volume	9
Issue number	3
DOIs	https://doi.org/10.4161/cc.9.3.10541
State	Published - Feb 1 2010

Keywords

Epidermis
Keratinocyte
Knockout mice
Multistage chemical skin carcinogenesis
p38δ signaling

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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10.4161/cc.9.3.10541

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title = "p38δ mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis",

abstract = "The p38δ mitogen-activated protein kinase (MAPK) is abundantly expressed in a wide array of tissues where it is likely to have specific functions. This review aims to highlight recent new insights into the biological roles of this relatively less studied p38 isoform. We focus on function of p38δ in regulating of epidermal keratinocyte differentiation, apoptosis and skin tumor development.",

keywords = "Epidermis, Keratinocyte, Knockout mice, Multistage chemical skin carcinogenesis, p38δ signaling",

author = "Tatiana Efimova",

note = "Funding Information: This work was supported by Dermatology Foundation Research Career Development Award and Research Grant, American Cancer Society Institutional Research Grant, American Skin Association Research Grant, funds from the Division of Dermatology, Washington University School of Medicine s(T. Efimova).",

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doi = "10.4161/cc.9.3.10541",

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AU - Efimova, Tatiana

N1 - Funding Information: This work was supported by Dermatology Foundation Research Career Development Award and Research Grant, American Cancer Society Institutional Research Grant, American Skin Association Research Grant, funds from the Division of Dermatology, Washington University School of Medicine s(T. Efimova).

PY - 2010/2/1

Y1 - 2010/2/1

N2 - The p38δ mitogen-activated protein kinase (MAPK) is abundantly expressed in a wide array of tissues where it is likely to have specific functions. This review aims to highlight recent new insights into the biological roles of this relatively less studied p38 isoform. We focus on function of p38δ in regulating of epidermal keratinocyte differentiation, apoptosis and skin tumor development.

AB - The p38δ mitogen-activated protein kinase (MAPK) is abundantly expressed in a wide array of tissues where it is likely to have specific functions. This review aims to highlight recent new insights into the biological roles of this relatively less studied p38 isoform. We focus on function of p38δ in regulating of epidermal keratinocyte differentiation, apoptosis and skin tumor development.

KW - Epidermis

KW - Keratinocyte

KW - Knockout mice

KW - Multistage chemical skin carcinogenesis

KW - p38δ signaling

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DO - 10.4161/cc.9.3.10541

M3 - Review article

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SP - 498

EP - 505

JO - Cell Cycle

JF - Cell Cycle

IS - 3

ER -

p38δ mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis

Abstract

Keywords

ASJC Scopus subject areas

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