p38 mitogen-activated protein kinases on the body surface-a function for p38δ

Richard L. Eckert; Tatiana Efimova; Sivaprakasam Balasubramanian; James F. Crish; Frederic Bone; Shervin Dashti

doi:10.1046/j.1523-1747.2003.12120.x

p38 mitogen-activated protein kinases on the body surface-a function for p38δ

Richard L. Eckert^*, Tatiana Efimova, Sivaprakasam Balasubramanian, James F. Crish, Frederic Bone, Shervin Dashti

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

The p38 family of mitogen-activated protein kinases includes p38α (SAPK2a, CSBP), p38β (SAPK2b), p386 (SAPK4), and p38y (SAPK3/ERK6). p38α and p38β are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress. Relatively less is known regarding the function of the p386 isoform. In this review, we discuss the role of the p38α, p38β, and p38γ isoforms and then present recent findings that define a role for p386 as a regulator of differentiation-dependent gene expression in keratinocytes.

Original language	English (US)
Pages (from-to)	823-828
Number of pages	6
Journal	Journal of Investigative Dermatology
Volume	120
Issue number	5
DOIs	https://doi.org/10.1046/j.1523-1747.2003.12120.x
State	Published - May 1 2003

Funding

This work utilized the facilities of the Skin Diseases Research Center of Northeast Ohio (NIH, AR39750) and was supported by grants from the National Institutes of Health (RLE). Dr Efimova was supported by a Dermatology Foundation Fellowship.

Keywords

Apoptosis
ERK
Involucrin
Keratinocyte differentiation
MAPK
Signal
Transduction
p38 MAPK
p38γ
p38δ

ASJC Scopus subject areas

Dermatology
Molecular Biology
Biochemistry
Cell Biology

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10.1046/j.1523-1747.2003.12120.x

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title = "p38 mitogen-activated protein kinases on the body surface-a function for p38δ",

abstract = "The p38 family of mitogen-activated protein kinases includes p38α (SAPK2a, CSBP), p38β (SAPK2b), p386 (SAPK4), and p38y (SAPK3/ERK6). p38α and p38β are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress. Relatively less is known regarding the function of the p386 isoform. In this review, we discuss the role of the p38α, p38β, and p38γ isoforms and then present recent findings that define a role for p386 as a regulator of differentiation-dependent gene expression in keratinocytes.",

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author = "Eckert, {Richard L.} and Tatiana Efimova and Sivaprakasam Balasubramanian and Crish, {James F.} and Frederic Bone and Shervin Dashti",

note = "Funding Information: This work utilized the facilities of the Skin Diseases Research Center of Northeast Ohio (NIH, AR39750) and was supported by grants from the National Institutes of Health (RLE). Dr Efimova was supported by a Dermatology Foundation Fellowship.",

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doi = "10.1046/j.1523-1747.2003.12120.x",

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AU - Efimova, Tatiana

AU - Balasubramanian, Sivaprakasam

AU - Crish, James F.

AU - Bone, Frederic

AU - Dashti, Shervin

N1 - Funding Information: This work utilized the facilities of the Skin Diseases Research Center of Northeast Ohio (NIH, AR39750) and was supported by grants from the National Institutes of Health (RLE). Dr Efimova was supported by a Dermatology Foundation Fellowship.

PY - 2003/5/1

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N2 - The p38 family of mitogen-activated protein kinases includes p38α (SAPK2a, CSBP), p38β (SAPK2b), p386 (SAPK4), and p38y (SAPK3/ERK6). p38α and p38β are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress. Relatively less is known regarding the function of the p386 isoform. In this review, we discuss the role of the p38α, p38β, and p38γ isoforms and then present recent findings that define a role for p386 as a regulator of differentiation-dependent gene expression in keratinocytes.

AB - The p38 family of mitogen-activated protein kinases includes p38α (SAPK2a, CSBP), p38β (SAPK2b), p386 (SAPK4), and p38y (SAPK3/ERK6). p38α and p38β are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress. Relatively less is known regarding the function of the p386 isoform. In this review, we discuss the role of the p38α, p38β, and p38γ isoforms and then present recent findings that define a role for p386 as a regulator of differentiation-dependent gene expression in keratinocytes.

KW - Apoptosis

KW - ERK

KW - Involucrin

KW - Keratinocyte differentiation

KW - MAPK

KW - Signal

KW - Transduction

KW - p38 MAPK

KW - p38γ

KW - p38δ

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ER -

p38 mitogen-activated protein kinases on the body surface-a function for p38δ

Abstract

Funding

Keywords

ASJC Scopus subject areas

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