p38 mitogen-activated protein kinases on the body surface-a function for p38δ

Richard L. Eckert*, Tatiana Efimova, Sivaprakasam Balasubramanian, James F. Crish, Frederic Bone, Shervin Dashti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


The p38 family of mitogen-activated protein kinases includes p38α (SAPK2a, CSBP), p38β (SAPK2b), p386 (SAPK4), and p38y (SAPK3/ERK6). p38α and p38β are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress. Relatively less is known regarding the function of the p386 isoform. In this review, we discuss the role of the p38α, p38β, and p38γ isoforms and then present recent findings that define a role for p386 as a regulator of differentiation-dependent gene expression in keratinocytes.

Original languageEnglish (US)
Pages (from-to)823-828
Number of pages6
JournalJournal of Investigative Dermatology
Issue number5
StatePublished - May 1 2003


  • Apoptosis
  • ERK
  • Involucrin
  • Keratinocyte differentiation
  • MAPK
  • Signal
  • Transduction
  • p38 MAPK
  • p38γ
  • p38δ

ASJC Scopus subject areas

  • Dermatology
  • Molecular Biology
  • Biochemistry
  • Cell Biology


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