P53 tumor suppression network in cancer epigenetics

Alok Mishra*, Daniel J. Brat, Mukesh Verma

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The tumor suppressor p53 is one of the most complex and widely studied genes in cancer biology. In spite of the vast on literature the transcriptional regulation of p53, aspects of its especially epigenetic regulation are not completely understood. This chapter presents a concise overview of p53-related epigenetic events involved in oncogenesis and tumor suppression. We limit the scope to epigenetic modifications of the p53 promoter per se as well as its well-established downstream targets. The indirect role of p53 affecting the epigenetic machinery of cancer cells via specific proteins and transcription factors is discussed. Current concepts of p53-related cancer epigenetics offer myriad avenues for cancer therapies. Challenges in the field are also discussed.

Original languageEnglish (US)
Title of host publicationCancer Epigenetics
Subtitle of host publicationRisk Assessment, Diagnosis, Treatment, and Prognosis
PublisherSpringer New York
Pages597-605
Number of pages9
ISBN (Electronic)9781493918041
ISBN (Print)9781493918034
DOIs
StatePublished - Nov 24 2014

Keywords

  • Acetylation
  • Cancer
  • ChIP
  • Chromatin
  • Epigenetic
  • Histones
  • Methylation
  • Micro RNA
  • p53

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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