TY - JOUR
T1 - Paclitaxel-terminated peptide brush polymers
AU - Zhu, Jialei
AU - Sun, Hao
AU - Callmann, Cassandra E.
AU - Callmann, Cassandra E.
AU - Thompson, Matthew P.
AU - Thompson, Matthew P.
AU - Battistella, Claudia
AU - Proetto, Maria T.
AU - Proetto, Maria T.
AU - Carlini, Andrea S.
AU - Carlini, Andrea S.
AU - Gianneschi, Nathan C.
AU - Gianneschi, Nathan C.
N1 - Publisher Copyright:
© 2020 The Royal Society of Chemistry.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/25
Y1 - 2020/6/25
N2 - In this paper, we report the preparation of paclitaxel-terminated peptide brush polymers wherein cell uptake and toxicity are tunable based on peptide sequence. Synthesis was enabled using a new paclitaxel-containing chain termination agent for ring-opening metathesis polymerization (ROMP). Critically, reverse phase HPLC could be used to efficiently separate peptide brush polymers consisting of one fluorophore and one terminal paclitaxel from crude polymer mixtures. These purified terminally-modified polymers showed greater potency than the original mixtures. Drug-terminated peptide brush polymers carrying positive charges exhibited enhanced cell uptake and cytotoxicity as compared to their neutral and negatively charged analogues. This journal is
AB - In this paper, we report the preparation of paclitaxel-terminated peptide brush polymers wherein cell uptake and toxicity are tunable based on peptide sequence. Synthesis was enabled using a new paclitaxel-containing chain termination agent for ring-opening metathesis polymerization (ROMP). Critically, reverse phase HPLC could be used to efficiently separate peptide brush polymers consisting of one fluorophore and one terminal paclitaxel from crude polymer mixtures. These purified terminally-modified polymers showed greater potency than the original mixtures. Drug-terminated peptide brush polymers carrying positive charges exhibited enhanced cell uptake and cytotoxicity as compared to their neutral and negatively charged analogues. This journal is
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U2 - 10.1039/c9cc10023g
DO - 10.1039/c9cc10023g
M3 - Article
C2 - 32441281
AN - SCOPUS:85087097044
VL - 56
SP - 6778
EP - 6781
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 50
ER -