Pain and Urinary Symptoms Should Not be Combined into a Single Score: Psychometric Findings from the MAPP Research Network

James W. Griffith*, Alisa J. Stephens-Shields, Xiaoling Hou, Bruce D. Naliboff, Michel Pontari, Todd C. Edwards, David A. Williams, J. Quentin Clemens, Niloofar Afari, Frank Tu, R. Brett Lloyd, Donald L. Patrick, Chris Mullins, John W. Kusek, Siobhan Sutcliffe, Barry A. Hong, H. Henry Lai, John N. Krieger, Catherine S. Bradley, Jayoung KimJ. Richard Landis

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose The purpose of this study was to create symptom indexes, that is scores derived from questionnaires to accurately and efficiently measure symptoms of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, collectively referred to as urological chronic pelvic pain syndromes. We created these indexes empirically by investigating the structure of symptoms using exploratory factor analysis. Materials and Methods As part of the MAPP (Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain) Research Network 424 participants completed questionnaires, including GUPI (Genitourinary Pain Index), ICSI (Interstitial Cystitis Symptom Index) and ICPI (Interstitial Cystitis Problem Index). Individual items from questionnaires about bladder and pain symptoms were evaluated by principal component and exploratory factor analyses to identify indexes with fewer questions to comprehensively quantify symptom severity. Additional analyses included correlating symptom indexes with symptoms of depression, which is a known comorbidity of patients with pelvic pain. Results and Conclusions Exploratory factor analyses suggested that the 2 factors pain severity and urinary severity provided the best psychometric description of items in GUPI, ICSI and ICPI. These factors were used to create 2 symptom indexes for pain and urinary symptoms. Pain, but not urinary symptoms, was associated with symptoms of depression on multiple regression analysis, suggesting that these symptoms may impact patients with urological chronic pelvic pain syndromes differently (B ± SE for pain severity = 0.24 ± 0.04, 95% CI 0.16–0.32, β = 0.32, p <0.001). Our results suggest that pain and urinary symptoms should be assessed separately rather than combined into 1 total score. Total scores that combine the separate factors of pain and urinary symptoms into 1 score may be limited for clinical and research purposes.

Original languageEnglish (US)
Pages (from-to)949-954
Number of pages6
JournalJournal of Urology
Volume195
Issue number4
DOIs
StatePublished - Apr 1 2016

Fingerprint

Psychometrics
Interstitial Cystitis
Pelvic Pain
Pain
Chronic Pain
Research
Statistical Factor Analysis
Urinary Bladder
Depression
Prostatitis
Comorbidity
Regression Analysis

Keywords

  • chronic pain
  • cystitis, interstitial
  • factor analysis, statistical
  • prostatitis
  • urinary bladder

ASJC Scopus subject areas

  • Urology

Cite this

Griffith, James W. ; Stephens-Shields, Alisa J. ; Hou, Xiaoling ; Naliboff, Bruce D. ; Pontari, Michel ; Edwards, Todd C. ; Williams, David A. ; Clemens, J. Quentin ; Afari, Niloofar ; Tu, Frank ; Lloyd, R. Brett ; Patrick, Donald L. ; Mullins, Chris ; Kusek, John W. ; Sutcliffe, Siobhan ; Hong, Barry A. ; Lai, H. Henry ; Krieger, John N. ; Bradley, Catherine S. ; Kim, Jayoung ; Landis, J. Richard. / Pain and Urinary Symptoms Should Not be Combined into a Single Score : Psychometric Findings from the MAPP Research Network. In: Journal of Urology. 2016 ; Vol. 195, No. 4. pp. 949-954.
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abstract = "Purpose The purpose of this study was to create symptom indexes, that is scores derived from questionnaires to accurately and efficiently measure symptoms of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, collectively referred to as urological chronic pelvic pain syndromes. We created these indexes empirically by investigating the structure of symptoms using exploratory factor analysis. Materials and Methods As part of the MAPP (Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain) Research Network 424 participants completed questionnaires, including GUPI (Genitourinary Pain Index), ICSI (Interstitial Cystitis Symptom Index) and ICPI (Interstitial Cystitis Problem Index). Individual items from questionnaires about bladder and pain symptoms were evaluated by principal component and exploratory factor analyses to identify indexes with fewer questions to comprehensively quantify symptom severity. Additional analyses included correlating symptom indexes with symptoms of depression, which is a known comorbidity of patients with pelvic pain. Results and Conclusions Exploratory factor analyses suggested that the 2 factors pain severity and urinary severity provided the best psychometric description of items in GUPI, ICSI and ICPI. These factors were used to create 2 symptom indexes for pain and urinary symptoms. Pain, but not urinary symptoms, was associated with symptoms of depression on multiple regression analysis, suggesting that these symptoms may impact patients with urological chronic pelvic pain syndromes differently (B ± SE for pain severity = 0.24 ± 0.04, 95{\%} CI 0.16–0.32, β = 0.32, p <0.001). Our results suggest that pain and urinary symptoms should be assessed separately rather than combined into 1 total score. Total scores that combine the separate factors of pain and urinary symptoms into 1 score may be limited for clinical and research purposes.",
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author = "Griffith, {James W.} and Stephens-Shields, {Alisa J.} and Xiaoling Hou and Naliboff, {Bruce D.} and Michel Pontari and Edwards, {Todd C.} and Williams, {David A.} and Clemens, {J. Quentin} and Niloofar Afari and Frank Tu and Lloyd, {R. Brett} and Patrick, {Donald L.} and Chris Mullins and Kusek, {John W.} and Siobhan Sutcliffe and Hong, {Barry A.} and Lai, {H. Henry} and Krieger, {John N.} and Bradley, {Catherine S.} and Jayoung Kim and Landis, {J. Richard}",
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Griffith, JW, Stephens-Shields, AJ, Hou, X, Naliboff, BD, Pontari, M, Edwards, TC, Williams, DA, Clemens, JQ, Afari, N, Tu, F, Lloyd, RB, Patrick, DL, Mullins, C, Kusek, JW, Sutcliffe, S, Hong, BA, Lai, HH, Krieger, JN, Bradley, CS, Kim, J & Landis, JR 2016, 'Pain and Urinary Symptoms Should Not be Combined into a Single Score: Psychometric Findings from the MAPP Research Network', Journal of Urology, vol. 195, no. 4, pp. 949-954. https://doi.org/10.1016/j.juro.2015.11.012

Pain and Urinary Symptoms Should Not be Combined into a Single Score : Psychometric Findings from the MAPP Research Network. / Griffith, James W.; Stephens-Shields, Alisa J.; Hou, Xiaoling; Naliboff, Bruce D.; Pontari, Michel; Edwards, Todd C.; Williams, David A.; Clemens, J. Quentin; Afari, Niloofar; Tu, Frank; Lloyd, R. Brett; Patrick, Donald L.; Mullins, Chris; Kusek, John W.; Sutcliffe, Siobhan; Hong, Barry A.; Lai, H. Henry; Krieger, John N.; Bradley, Catherine S.; Kim, Jayoung; Landis, J. Richard.

In: Journal of Urology, Vol. 195, No. 4, 01.04.2016, p. 949-954.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pain and Urinary Symptoms Should Not be Combined into a Single Score

T2 - Psychometric Findings from the MAPP Research Network

AU - Griffith, James W.

AU - Stephens-Shields, Alisa J.

AU - Hou, Xiaoling

AU - Naliboff, Bruce D.

AU - Pontari, Michel

AU - Edwards, Todd C.

AU - Williams, David A.

AU - Clemens, J. Quentin

AU - Afari, Niloofar

AU - Tu, Frank

AU - Lloyd, R. Brett

AU - Patrick, Donald L.

AU - Mullins, Chris

AU - Kusek, John W.

AU - Sutcliffe, Siobhan

AU - Hong, Barry A.

AU - Lai, H. Henry

AU - Krieger, John N.

AU - Bradley, Catherine S.

AU - Kim, Jayoung

AU - Landis, J. Richard

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Purpose The purpose of this study was to create symptom indexes, that is scores derived from questionnaires to accurately and efficiently measure symptoms of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, collectively referred to as urological chronic pelvic pain syndromes. We created these indexes empirically by investigating the structure of symptoms using exploratory factor analysis. Materials and Methods As part of the MAPP (Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain) Research Network 424 participants completed questionnaires, including GUPI (Genitourinary Pain Index), ICSI (Interstitial Cystitis Symptom Index) and ICPI (Interstitial Cystitis Problem Index). Individual items from questionnaires about bladder and pain symptoms were evaluated by principal component and exploratory factor analyses to identify indexes with fewer questions to comprehensively quantify symptom severity. Additional analyses included correlating symptom indexes with symptoms of depression, which is a known comorbidity of patients with pelvic pain. Results and Conclusions Exploratory factor analyses suggested that the 2 factors pain severity and urinary severity provided the best psychometric description of items in GUPI, ICSI and ICPI. These factors were used to create 2 symptom indexes for pain and urinary symptoms. Pain, but not urinary symptoms, was associated with symptoms of depression on multiple regression analysis, suggesting that these symptoms may impact patients with urological chronic pelvic pain syndromes differently (B ± SE for pain severity = 0.24 ± 0.04, 95% CI 0.16–0.32, β = 0.32, p <0.001). Our results suggest that pain and urinary symptoms should be assessed separately rather than combined into 1 total score. Total scores that combine the separate factors of pain and urinary symptoms into 1 score may be limited for clinical and research purposes.

AB - Purpose The purpose of this study was to create symptom indexes, that is scores derived from questionnaires to accurately and efficiently measure symptoms of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, collectively referred to as urological chronic pelvic pain syndromes. We created these indexes empirically by investigating the structure of symptoms using exploratory factor analysis. Materials and Methods As part of the MAPP (Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain) Research Network 424 participants completed questionnaires, including GUPI (Genitourinary Pain Index), ICSI (Interstitial Cystitis Symptom Index) and ICPI (Interstitial Cystitis Problem Index). Individual items from questionnaires about bladder and pain symptoms were evaluated by principal component and exploratory factor analyses to identify indexes with fewer questions to comprehensively quantify symptom severity. Additional analyses included correlating symptom indexes with symptoms of depression, which is a known comorbidity of patients with pelvic pain. Results and Conclusions Exploratory factor analyses suggested that the 2 factors pain severity and urinary severity provided the best psychometric description of items in GUPI, ICSI and ICPI. These factors were used to create 2 symptom indexes for pain and urinary symptoms. Pain, but not urinary symptoms, was associated with symptoms of depression on multiple regression analysis, suggesting that these symptoms may impact patients with urological chronic pelvic pain syndromes differently (B ± SE for pain severity = 0.24 ± 0.04, 95% CI 0.16–0.32, β = 0.32, p <0.001). Our results suggest that pain and urinary symptoms should be assessed separately rather than combined into 1 total score. Total scores that combine the separate factors of pain and urinary symptoms into 1 score may be limited for clinical and research purposes.

KW - chronic pain

KW - cystitis, interstitial

KW - factor analysis, statistical

KW - prostatitis

KW - urinary bladder

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