Abstract
Noninvasive brain imaging has established the participation of the cortex in pain perception and identified a long list of brain structures involved. More recent studies show the interaction between clinical chronic pain conditions and the reorganization of the brain functionally, anatomically, and chemically. Mechanisms underlying this reorganization hint to essential links between pain, especially its affective component with emotional learning and memory. This review is a discussion of the rationale and evidence for the interaction between these modalities, emphasizing underlying mechanisms.
Original language | English (US) |
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Pages (from-to) | 464-468 |
Number of pages | 5 |
Journal | Current opinion in neurobiology |
Volume | 18 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2008 |
Funding
The author thanks all the patients and volunteers who have contributed to the science we have generated over the last decade or so, as well as all the students and collaborating colleagues. This work was supported by NIH NINDS grants NS35115, NS53602, and NS57704.
ASJC Scopus subject areas
- General Neuroscience