Palatal myoclonus, abnormal eye movements, and olivary hypertrophy in GAD65-related disorder

Gabrielle MacAron, Mary A. Willis, Daniel Ontaneda, Hubert Fernandez, Sanghoon Kim, Stephen E. Jones, Erik P. Pioro, Jeffrey A. Cohen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Antibodies targeting the 65-kilodalton isoform of glutamic acid decarboxylase (GAD65) are implicated in several autoimmune neurologic disorders.1 Anti-GAD65 antibodies (GAD65-Abs) can be seen in healthy individuals, highlighting the importance of interpreting their significance in the appropriate clinical context.1 Classic neurologic presentations include stiff-person syndrome, cerebellar ataxia, limbic encephalitis, epilepsy, myelopathy, other brainstem manifestations, and extrapyramidal symptoms.1-3 A few cases of focal myoclonus have been described.2 There is one previous report of palatal myoclonus with normal brain MRI.4 We report a patient with GAD65-Abs with relapsing diplopia, cerebellar syndrome, and palatal myoclonus with hypertrophy of the inferior olivary nuclei (ION) seen on 1.5T MRI and a dentato-rubro-olivary pathway lesion on 7T MRI.

Original languageEnglish (US)
Pages (from-to)273-275
Number of pages3
Issue number6
StatePublished - Feb 11 2020

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Palatal myoclonus, abnormal eye movements, and olivary hypertrophy in GAD65-related disorder'. Together they form a unique fingerprint.

Cite this