Palladium-Catalyzed Coupling Reactions on Functionalized 2-Trifluoromethyl-4-chromenone Scaffolds: Synthesis of Highly Functionalized Trifluoromethyl Heterocycles

Javier Izquierdo, Atul D. Jain, Sarki A. Abdulkadir, Gary E. Schiltz

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The chromenone core is an ubiquitous group in biologically active natural products and has been extensively used in organic synthesis. Fluorine-derived compounds, including those with a trifluoromethyl group (CF 3 ), have shown enhanced biological activities in numerous pharmaceuticals compared with their non-fluorinated analogues. 2-Trifluoromethylchromenones can be readily functionalized at the 8- and 7-positions, providing chromenones cores of high structural complexity, which are excellent precursors for numerous trifluoromethyl heterocycles.

Original languageEnglish (US)
Pages (from-to)1342-1352
Number of pages11
JournalSynthesis (Germany)
Volume51
Issue number6
DOIs
StatePublished - Jan 1 2019

Keywords

  • chromenone
  • fluorine
  • palladium-catalyzed coupling
  • trifluoromethyl heterocycle synthesis

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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