Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF2H

Devin M. Ferguson, Christian A. Malapit, James R. Bour, Melanie S. Sanford*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A palladium-catalyzed cross-coupling of aryl chlorides/bromides with TMSCF2H is described. Two different catalysts, Pd(dba)2/BrettPhos and Pd(PtBu3)2, are demonstrated and provide a variety of difluoromethylated arenes in good yields.

Original languageEnglish (US)
Pages (from-to)3735-3740
Number of pages6
JournalJournal of Organic Chemistry
Volume84
Issue number6
DOIs
StatePublished - Mar 15 2019

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF2H'. Together they form a unique fingerprint.

Cite this