Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF2H

Devin M. Ferguson; Christian A. Malapit; James R. Bour; Melanie S. Sanford

doi:10.1021/acs.joc.9b00324

Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF₂H

Devin M. Ferguson, Christian A. Malapit, James R. Bour, Melanie S. Sanford^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A palladium-catalyzed cross-coupling of aryl chlorides/bromides with TMSCF₂H is described. Two different catalysts, Pd(dba)₂/BrettPhos and Pd(P^tBu₃)₂, are demonstrated and provide a variety of difluoromethylated arenes in good yields.

Original language	English (US)
Pages (from-to)	3735-3740
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	84
Issue number	6
DOIs	https://doi.org/10.1021/acs.joc.9b00324
State	Published - Mar 15 2019
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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title = "Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF2H",

abstract = "A palladium-catalyzed cross-coupling of aryl chlorides/bromides with TMSCF2H is described. Two different catalysts, Pd(dba)2/BrettPhos and Pd(PtBu3)2, are demonstrated and provide a variety of difluoromethylated arenes in good yields.",

author = "Ferguson, {Devin M.} and Malapit, {Christian A.} and Bour, {James R.} and Sanford, {Melanie S.}",

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doi = "10.1021/acs.joc.9b00324",

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T1 - Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF2H

AU - Ferguson, Devin M.

AU - Malapit, Christian A.

AU - Bour, James R.

AU - Sanford, Melanie S.

PY - 2019/3/15

Y1 - 2019/3/15

N2 - A palladium-catalyzed cross-coupling of aryl chlorides/bromides with TMSCF2H is described. Two different catalysts, Pd(dba)2/BrettPhos and Pd(PtBu3)2, are demonstrated and provide a variety of difluoromethylated arenes in good yields.

AB - A palladium-catalyzed cross-coupling of aryl chlorides/bromides with TMSCF2H is described. Two different catalysts, Pd(dba)2/BrettPhos and Pd(PtBu3)2, are demonstrated and provide a variety of difluoromethylated arenes in good yields.

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JF - Journal of Organic Chemistry

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Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF₂H

Abstract

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