Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Bromides with TMSCF2H

Devin M. Ferguson, Christian A. Malapit, James R. Bour, Melanie S. Sanford*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


A palladium-catalyzed cross-coupling of aryl chlorides/bromides with TMSCF2H is described. Two different catalysts, Pd(dba)2/BrettPhos and Pd(PtBu3)2, are demonstrated and provide a variety of difluoromethylated arenes in good yields.

Original languageEnglish (US)
Pages (from-to)3735-3740
Number of pages6
JournalJournal of Organic Chemistry
Issue number6
StatePublished - Mar 15 2019
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry


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