Abstract
Background: Mutations in SOD1 cause familial amyotrophic lateral sclerosis (ALS). Results: SOD1 undergoes palmitoylation in the spinal cord and multiple cell types. Palmitoylation occurs predominantly on immature SOD1 and is increased for ALS-linked SOD1 mutants. Conclusion: Palmitoylation is a reversible post-translational modification of SOD1 cysteine residues. Significance: Palmitoylation could affect SOD1 toxicity by altering its folding, membrane targeting, and/or function.
Original language | English (US) |
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Pages (from-to) | 21606-21617 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 30 |
DOIs | |
State | Published - Jul 26 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology