Pan-cytokeratin immunoexpression in Wilms' tumors: A simple approach for understanding tumor epithelial differentiation

Simone Treiger Sredni; José Ivanildo Neves; Beatriz de Camargo; Otávia Luiza Damas de Caballero; Fernando Augusto Soares

doi:10.1590/S1516-31802004000400011

Pan-cytokeratin immunoexpression in Wilms' tumors: A simple approach for understanding tumor epithelial differentiation

Simone Treiger Sredni^*, José Ivanildo Neves, Beatriz de Camargo, Otávia Luiza Damas de Caballero, Fernando Augusto Soares

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Wilms' tumor is one of the most common solid tumors in children and is an interesting model for understanding the pathogenesis of embryonal tumors. Cytokeratins are intracellular fibrous proteins present in tissue of epithelial origin. The immunoexpression of the pan-cytokeratin AE1 AE3 was studied in paraffin-embedded tissue sections from 24 Wilms' tumors (12 with nephrogenic rests) and also tissue samples from 15 corresponding normal kidneys, to evaluate epithelial differentiation in the genesis of Wilms' tumor. We observed that the intensity of the expression of AE1 AE3 in the epithelial component of Wilms' tumors directly correlated with the degree of maturity of the epithelial structures correspondents to the collecting ducts.

Original language	English (US)
Pages (from-to)	181-183
Number of pages	3
Journal	Sao Paulo Medical Journal
Volume	122
Issue number	4
DOIs	https://doi.org/10.1590/S1516-31802004000400011
State	Published - Jul 1 2004

Keywords

Cytokeratin
Immunohistochemistry
Kidney neoplasms
Wilms' tumor

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1590/S1516-31802004000400011

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title = "Pan-cytokeratin immunoexpression in Wilms' tumors: A simple approach for understanding tumor epithelial differentiation",

abstract = "Wilms' tumor is one of the most common solid tumors in children and is an interesting model for understanding the pathogenesis of embryonal tumors. Cytokeratins are intracellular fibrous proteins present in tissue of epithelial origin. The immunoexpression of the pan-cytokeratin AE1 AE3 was studied in paraffin-embedded tissue sections from 24 Wilms' tumors (12 with nephrogenic rests) and also tissue samples from 15 corresponding normal kidneys, to evaluate epithelial differentiation in the genesis of Wilms' tumor. We observed that the intensity of the expression of AE1 AE3 in the epithelial component of Wilms' tumors directly correlated with the degree of maturity of the epithelial structures correspondents to the collecting ducts.",

keywords = "Cytokeratin, Immunohistochemistry, Kidney neoplasms, Wilms' tumor",

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T2 - A simple approach for understanding tumor epithelial differentiation

AU - Sredni, Simone Treiger

AU - Neves, José Ivanildo

AU - de Camargo, Beatriz

AU - Damas de Caballero, Otávia Luiza

AU - Soares, Fernando Augusto

PY - 2004/7/1

Y1 - 2004/7/1

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AB - Wilms' tumor is one of the most common solid tumors in children and is an interesting model for understanding the pathogenesis of embryonal tumors. Cytokeratins are intracellular fibrous proteins present in tissue of epithelial origin. The immunoexpression of the pan-cytokeratin AE1 AE3 was studied in paraffin-embedded tissue sections from 24 Wilms' tumors (12 with nephrogenic rests) and also tissue samples from 15 corresponding normal kidneys, to evaluate epithelial differentiation in the genesis of Wilms' tumor. We observed that the intensity of the expression of AE1 AE3 in the epithelial component of Wilms' tumors directly correlated with the degree of maturity of the epithelial structures correspondents to the collecting ducts.

KW - Cytokeratin

KW - Immunohistochemistry

KW - Kidney neoplasms

KW - Wilms' tumor

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Pan-cytokeratin immunoexpression in Wilms' tumors: A simple approach for understanding tumor epithelial differentiation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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