Pancreatic blastomatous tumor in a child responding to therapy used for hepatoblastoma

Case report and review of the literature

Elaine R. Morgan*, John H. Perryman, Marleta Reynolds, Frank J. Gonzalez-Crussi

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A case is reported of a 7-year-old girl diagnosed with initially inoperable metastatic embryonic pancreatic tumor, which showed a significant clinical response to chemotherapeutic agents commonly used to treat hepatoblastoma. This regimen was selected because certain histologic features of the tumor demonstrated characteristics seen in hepatic tissue. After two courses of chemotherapy (cis-platinum and adriamycin), there was a significant reduction of the primary mass, and it was completely resected, although the tumor subsequently recurred in the metastatic, unoperated site. The embryologic relationship between the tumor in this patient and hepatoblastoma, as well as the literature concerning treatment in pediatric pancreatoblastic tumors are reviewed. Complete eradication of tumor appears to be necessary for cure.

Original languageEnglish (US)
Pages (from-to)284-292
Number of pages9
JournalMedical and Pediatric Oncology
Volume26
Issue number4
DOIs
StatePublished - Apr 1 1996

Fingerprint

Hepatoblastoma
Neoplasms
Therapeutics
Doxorubicin
Cisplatin
Pediatrics
Drug Therapy
Liver

Keywords

  • chemotherapy
  • embryology
  • pancreatic tumors
  • pancreatoblastoma
  • pediatric oncology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this

@article{02cf0a172a3543eb97a69b3b5ee0bdf3,
title = "Pancreatic blastomatous tumor in a child responding to therapy used for hepatoblastoma: Case report and review of the literature",
abstract = "A case is reported of a 7-year-old girl diagnosed with initially inoperable metastatic embryonic pancreatic tumor, which showed a significant clinical response to chemotherapeutic agents commonly used to treat hepatoblastoma. This regimen was selected because certain histologic features of the tumor demonstrated characteristics seen in hepatic tissue. After two courses of chemotherapy (cis-platinum and adriamycin), there was a significant reduction of the primary mass, and it was completely resected, although the tumor subsequently recurred in the metastatic, unoperated site. The embryologic relationship between the tumor in this patient and hepatoblastoma, as well as the literature concerning treatment in pediatric pancreatoblastic tumors are reviewed. Complete eradication of tumor appears to be necessary for cure.",
keywords = "chemotherapy, embryology, pancreatic tumors, pancreatoblastoma, pediatric oncology",
author = "Morgan, {Elaine R.} and Perryman, {John H.} and Marleta Reynolds and Gonzalez-Crussi, {Frank J.}",
year = "1996",
month = "4",
day = "1",
doi = "10.1002/(SICI)1096-911X(199604)26:4<284::AID-MPO13>3.0.CO;2-F",
language = "English (US)",
volume = "26",
pages = "284--292",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "4",

}

Pancreatic blastomatous tumor in a child responding to therapy used for hepatoblastoma : Case report and review of the literature. / Morgan, Elaine R.; Perryman, John H.; Reynolds, Marleta; Gonzalez-Crussi, Frank J.

In: Medical and Pediatric Oncology, Vol. 26, No. 4, 01.04.1996, p. 284-292.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pancreatic blastomatous tumor in a child responding to therapy used for hepatoblastoma

T2 - Case report and review of the literature

AU - Morgan, Elaine R.

AU - Perryman, John H.

AU - Reynolds, Marleta

AU - Gonzalez-Crussi, Frank J.

PY - 1996/4/1

Y1 - 1996/4/1

N2 - A case is reported of a 7-year-old girl diagnosed with initially inoperable metastatic embryonic pancreatic tumor, which showed a significant clinical response to chemotherapeutic agents commonly used to treat hepatoblastoma. This regimen was selected because certain histologic features of the tumor demonstrated characteristics seen in hepatic tissue. After two courses of chemotherapy (cis-platinum and adriamycin), there was a significant reduction of the primary mass, and it was completely resected, although the tumor subsequently recurred in the metastatic, unoperated site. The embryologic relationship between the tumor in this patient and hepatoblastoma, as well as the literature concerning treatment in pediatric pancreatoblastic tumors are reviewed. Complete eradication of tumor appears to be necessary for cure.

AB - A case is reported of a 7-year-old girl diagnosed with initially inoperable metastatic embryonic pancreatic tumor, which showed a significant clinical response to chemotherapeutic agents commonly used to treat hepatoblastoma. This regimen was selected because certain histologic features of the tumor demonstrated characteristics seen in hepatic tissue. After two courses of chemotherapy (cis-platinum and adriamycin), there was a significant reduction of the primary mass, and it was completely resected, although the tumor subsequently recurred in the metastatic, unoperated site. The embryologic relationship between the tumor in this patient and hepatoblastoma, as well as the literature concerning treatment in pediatric pancreatoblastic tumors are reviewed. Complete eradication of tumor appears to be necessary for cure.

KW - chemotherapy

KW - embryology

KW - pancreatic tumors

KW - pancreatoblastoma

KW - pediatric oncology

UR - http://www.scopus.com/inward/record.url?scp=0029867683&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029867683&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1096-911X(199604)26:4<284::AID-MPO13>3.0.CO;2-F

DO - 10.1002/(SICI)1096-911X(199604)26:4<284::AID-MPO13>3.0.CO;2-F

M3 - Article

VL - 26

SP - 284

EP - 292

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 4

ER -