Pancreatic necrosis and regeneration induced by 4 hydroxyaminoquinoline 1 oxide in the guinea pig

J. K. Reddy, M. S. Rao, D. J. Svoboda, J. D. Prasad

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24 Scopus citations

Abstract

A single intravenous injection of 4 hydroxyaminoquinoline 1 oxide, in a dose of 22.5 mg/kg induced marked necrosis of exocrine pancreas in inbred strain 13 guinea pigs within 48 hr. The pancreatic acinar cell necrosis was dose dependent and was associated with a significantly elevated serum amylase level and reduction in amylase activity in the pancreatic tissue. The maximal necrotic changes in the exocrine pancreas were observed at 48 hr. After the necrotic phase, a striking regenerative response of pancreatic acinar tissue ensued. 3H thymidine autoradiographic studies revealed a labeling index of 28% cells in several pancreatic lobules 66 hr after 4 hydroxyaminoquinoline 1 oxide injection. The acinar cell repair as well as formation of the new acini in many pancreatic lobules, was complete by 84 hr. In some pancreatic lobules, pseudoacinar or ductular transformation was noted. The regenerative response in pancreatic acinar tissue and ductal epithelium induced by 4 hydroxyaminoquinoline 1 oxide in the guinea pig appeared to be severalfold higher than that noted during ethionine regeneration.

Original languageEnglish (US)
Pages (from-to)98-104
Number of pages7
JournalLaboratory Investigation
Volume32
Issue number1
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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