Pancreatic Pain - Knowledge Gaps and Research Opportunities in Children and Adults: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

Aliye Uc; Dana K. Andersen; A. Vania Apkarian; Melena D. Bellin; Luana Colloca; Asbjørn M. Drewes; Ellyn K. Dunbar; Christopher E. Forsmark; Marc T. Goodman; Leonardo Kapural; George F. Koob; Tonya M. Palermo; Stephen J. Pandol; Pankaj Pasricha; Anna E. Phillips; Daniele Piomelli; Jami L. Saloman; Sarah Jane Schwarzenberg; Vikesh K. Singh; Gwendolyn Sowa; Thomas Strouse; Glenn J. Treisman; John A. Windsor; Dhiraj Yadav

doi:10.1097/MPA.0000000000001899

Pancreatic Pain - Knowledge Gaps and Research Opportunities in Children and Adults: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

Aliye Uc, Dana K. Andersen, A. Vania Apkarian, Melena D. Bellin, Luana Colloca, Asbjørn M. Drewes, Ellyn K. Dunbar, Christopher E. Forsmark, Marc T. Goodman, Leonardo Kapural, George F. Koob, Tonya M. Palermo, Stephen J. Pandol, Pankaj Pasricha, Anna E. Phillips, Daniele Piomelli, Jami L. Saloman, Sarah Jane Schwarzenberg, Vikesh K. Singh, Gwendolyn SowaThomas Strouse, Glenn J. Treisman, John A. Windsor, Dhiraj Yadav^*

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in pancreatic pain. The event was held on July 21, 2021, and structured into 4 sessions: (1) pathophysiology; (2) biomarkers, mediators, and pharmacology of pain; (3) pain assessment; and (4) pain treatment challenges and opportunities. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to better understand the underlying mechanisms of pain in pancreatic diseases, the relationship of visceral neural pathways and central pain centers, the role of behavioral factors and disorders on the perception of pain, and differences in pain perception and processes in children when compared with adults. In addition, the role of genetic risk factors for pain and the mechanisms and role of placebos in pain treatment were discussed. Methods of pain assessment including quantitative sensory testing were examined, as well as the process of central sensitization of pain. Finally, newer approaches to pain management including cognitive behavioral therapy, nerve stimulation, experimental (nonopioid) drugs, and cannabinoid compounds were covered.

Original language	English (US)
Pages (from-to)	906-915
Number of pages	10
Journal	Pancreas
Volume	50
Issue number	7
DOIs	https://doi.org/10.1097/MPA.0000000000001899
State	Published - Aug 1 2021

Funding

The Back Pain Consortium (BACPAC) Research Program is administered by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and part of the NIH HEAL Network. Funding for the workshop was provided by National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. A.U. is a member of the American Board of Pediatrics, Subboard of Pediatric Gastroenterology; a member of the American Pancreatic Association Governing Board; an associate editor of the Pancreatology; and a consultant of the Cystic Fibrosis Foundation. M.D.B. is a consultant/DSMB member of the Insulet and received research support from ViaCyte and Dexcom. C.E.F. is a consultant of Nestle, received research support from AbbVie, and a board member of the National Pancreas Foundation. L.K. received research support from Medtronic, Nevro, Gimer, Neuros, and SPR Therapeutics; a member of the scientific advisory board of Biotronik and Nalu; and a consultant of Avanos, Nevro, and Nalu. The other authors declare no conflict of interest.

Keywords

central sensitization
pancreatic cancer
pancreatitis
peripheral sensitization
placebo
quantitative sensory testing

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Hepatology
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/MPA.0000000000001899

Cite this

Uc, A., Andersen, D. K., Apkarian, A. V., Bellin, M. D., Colloca, L., Drewes, A. M., Dunbar, E. K., Forsmark, C. E., Goodman, M. T., Kapural, L., Koob, G. F., Palermo, T. M., Pandol, S. J., Pasricha, P., Phillips, A. E., Piomelli, D., Saloman, J. L., Schwarzenberg, S. J., Singh, V. K., ... Yadav, D. (2021). Pancreatic Pain - Knowledge Gaps and Research Opportunities in Children and Adults: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas, 50(7), 906-915. https://doi.org/10.1097/MPA.0000000000001899

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title = "Pancreatic Pain - Knowledge Gaps and Research Opportunities in Children and Adults: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop",

abstract = "A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in pancreatic pain. The event was held on July 21, 2021, and structured into 4 sessions: (1) pathophysiology; (2) biomarkers, mediators, and pharmacology of pain; (3) pain assessment; and (4) pain treatment challenges and opportunities. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to better understand the underlying mechanisms of pain in pancreatic diseases, the relationship of visceral neural pathways and central pain centers, the role of behavioral factors and disorders on the perception of pain, and differences in pain perception and processes in children when compared with adults. In addition, the role of genetic risk factors for pain and the mechanisms and role of placebos in pain treatment were discussed. Methods of pain assessment including quantitative sensory testing were examined, as well as the process of central sensitization of pain. Finally, newer approaches to pain management including cognitive behavioral therapy, nerve stimulation, experimental (nonopioid) drugs, and cannabinoid compounds were covered.",

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Uc, A, Andersen, DK, Apkarian, AV, Bellin, MD, Colloca, L, Drewes, AM, Dunbar, EK, Forsmark, CE, Goodman, MT, Kapural, L, Koob, GF, Palermo, TM, Pandol, SJ, Pasricha, P, Phillips, AE, Piomelli, D, Saloman, JL, Schwarzenberg, SJ, Singh, VK, Sowa, G, Strouse, T, Treisman, GJ, Windsor, JA & Yadav, D 2021, 'Pancreatic Pain - Knowledge Gaps and Research Opportunities in Children and Adults: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop', Pancreas, vol. 50, no. 7, pp. 906-915. https://doi.org/10.1097/MPA.0000000000001899

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AU - Uc, Aliye

AU - Andersen, Dana K.

AU - Apkarian, A. Vania

AU - Bellin, Melena D.

AU - Colloca, Luana

AU - Drewes, Asbjørn M.

AU - Dunbar, Ellyn K.

AU - Forsmark, Christopher E.

AU - Goodman, Marc T.

AU - Kapural, Leonardo

AU - Koob, George F.

AU - Palermo, Tonya M.

AU - Pandol, Stephen J.

AU - Pasricha, Pankaj

AU - Phillips, Anna E.

AU - Piomelli, Daniele

AU - Saloman, Jami L.

AU - Schwarzenberg, Sarah Jane

AU - Singh, Vikesh K.

AU - Sowa, Gwendolyn

AU - Strouse, Thomas

AU - Treisman, Glenn J.

AU - Windsor, John A.

AU - Yadav, Dhiraj

PY - 2021/8/1

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N2 - A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in pancreatic pain. The event was held on July 21, 2021, and structured into 4 sessions: (1) pathophysiology; (2) biomarkers, mediators, and pharmacology of pain; (3) pain assessment; and (4) pain treatment challenges and opportunities. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to better understand the underlying mechanisms of pain in pancreatic diseases, the relationship of visceral neural pathways and central pain centers, the role of behavioral factors and disorders on the perception of pain, and differences in pain perception and processes in children when compared with adults. In addition, the role of genetic risk factors for pain and the mechanisms and role of placebos in pain treatment were discussed. Methods of pain assessment including quantitative sensory testing were examined, as well as the process of central sensitization of pain. Finally, newer approaches to pain management including cognitive behavioral therapy, nerve stimulation, experimental (nonopioid) drugs, and cannabinoid compounds were covered.

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KW - pancreatic cancer

KW - pancreatitis

KW - peripheral sensitization

KW - placebo

KW - quantitative sensory testing

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Pancreatic Pain - Knowledge Gaps and Research Opportunities in Children and Adults: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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