Pancreatic Pain-Knowledge Gaps and Research Opportunities in Children and Adults: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

Aliye Uc, Dana K. Andersen, A. Vania Apkarian, Melena D. Bellin, Luana Colloca, Asbjørn M. Drewes, Ellyn K. Dunbar, Christopher E. Forsmark, Marc T. Goodman, Leonardo Kapural, George F. Koob, Tonya M. Palermo, Stephen J. Pandol, Pankaj Pasricha, Anna E. Phillips, Daniele Piomelli, Jami L. Saloman, Sarah Jane Schwarzenberg, Vikesh K. Singh, Gwendolyn SowaThomas Strouse, Glenn J. Treisman, John A. Windsor, Dhiraj Yadav

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

ABSTRACT: A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in pancreatic pain. The event was held on July 21, 2021, and structured into 4 sessions: (1) pathophysiology; (2) biomarkers, mediators, and pharmacology of pain; (3) pain assessment; and (4) pain treatment challenges and opportunities. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to better understand the underlying mechanisms of pain in pancreatic diseases, the relationship of visceral neural pathways and central pain centers, the role of behavioral factors and disorders on the perception of pain, and differences in pain perception and processes in children when compared with adults. In addition, the role of genetic risk factors for pain and the mechanisms and role of placebos in pain treatment were discussed. Methods of pain assessment including quantitative sensory testing were examined, as well as the process of central sensitization of pain. Finally, newer approaches to pain management including cognitive behavioral therapy, nerve stimulation, experimental (nonopioid) drugs, and cannabinoid compounds were covered.

Original languageEnglish (US)
Pages (from-to)906-915
Number of pages10
JournalPancreas
Volume50
Issue number7
DOIs
StatePublished - Aug 1 2021

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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