Pancreaticoduodenectomy and metastasectomy for metastatic pancreatic neuroendocrine tumors

Akhil Chawla, Richelle T. Williams, Nicholas Sich, Thomas Clancy, Jiping Wang, Stanley Ashley, Christopher Pezzi, Richard Swanson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background and Objectives: Various treatment options exist for patients with metastatic pancreatic neuroendocrine tumors (PNETs). Surgical resection with pancreaticoduodenectomy (PD) typically reserved for patients with limited disease. Definitive data are lacking to support either the resection of primary PNET in the metastatic setting or for surgical debulking of metastatic lesions. Methods: We conducted an analysis of the National Cancer Database (NCDB) using the pancreatic cancer Participant User File. Thirty- and 90-day mortality rates and survival rates were determined for patients undergoing PD for primary tumor resection and compared with patients who had no surgery or metastasectomy. The Kaplan-Meier method was used to compare survival time. Cox regression models were used to assess factors independently associated with overall survival time. Results: Resection of the primary tumor or metastatic disease each significantly improved overall survival time compared with no resection. Adding metastasectomy to PD resulted in an incremental increase in overall survival time. Both PD and metastasectomy are independently associated with overall survival time. Conclusions: Our report highlights the potential for survival time benefit in appropriately selected patients who undergo PD in the setting of metastatic PNET.

Original languageEnglish (US)
Pages (from-to)983-990
Number of pages8
JournalJournal of surgical oncology
Volume118
Issue number6
DOIs
StatePublished - Nov 1 2018
Externally publishedYes

Keywords

  • metastasectomy
  • metastatic pancreatic neuroendocrine tumor
  • pancreatic neuroendocrine tumor (PNET)
  • pancreaticoduodenectomy (PD)

ASJC Scopus subject areas

  • Surgery
  • Oncology

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