Paraclinical serum markers as aids in the diagnosis of autoimmune encephalitis

George Culler, Elizabeth Bachman, Stephen VanHaerents*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Expert opinion suggests the presence ANA and thyroid antibodies may be helpful to diagnosis autoimmune encephalitis (AE). This study investigates the sensitivity of these serum markers in a cohort of 26 patients with AE. TPO-Ab, TG-Ab and ANA (titer ≥1:320) were present in 45%, 35% and 32% of patients tested, respectively. The prevalence of TPO-Ab (11.3%), TG-Ab (10.4%) and ANA ≥1:320 (3.3%) has been previously reported in disease-free populations. Although these antibodies represent non-specific markers of autoimmunity, this study demonstrated that TPO-Ab, TG-Ab and ANA were significantly elevated in AE compared to disease-free populations (p <.001, p =.003, p <.001, respectively).

Original languageEnglish (US)
Article number577324
JournalJournal of Neuroimmunology
Volume347
DOIs
StatePublished - Oct 15 2020

Keywords

  • All immunology
  • Autoimmune disease
  • Encephalitis
  • Epilepsy
  • Paraneoplastic syndrome
  • Seizure

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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