TY - JOUR
T1 - Paradigm lost
T2 - Milton connects kinesin heavy chain to miro on mitochondria
AU - Rice, Sarah E.
AU - Gelfand, Vladimir I.
PY - 2006/5/22
Y1 - 2006/5/22
N2 - The kinesin motor typically binds to cargo through its light chains. In this issue Glater et al. (p. 545) demonstrate a new type of linkage through the adapter protein, milton, and the mitochondrial membrane GTPase, miro. This is an important result because it represents a new mechanism of cargo binding and because miro's ability to bind GTP and calcium suggests that it is involved in the regulation of mitochondrial transport.
AB - The kinesin motor typically binds to cargo through its light chains. In this issue Glater et al. (p. 545) demonstrate a new type of linkage through the adapter protein, milton, and the mitochondrial membrane GTPase, miro. This is an important result because it represents a new mechanism of cargo binding and because miro's ability to bind GTP and calcium suggests that it is involved in the regulation of mitochondrial transport.
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U2 - 10.1083/jcb.200604071
DO - 10.1083/jcb.200604071
M3 - Review article
C2 - 16717123
AN - SCOPUS:33646768564
SN - 0021-9525
VL - 173
SP - 459
EP - 461
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 4
ER -