Paradigm lost: Milton connects kinesin heavy chain to miro on mitochondria

Sarah E. Rice, Vladimir I. Gelfand*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

The kinesin motor typically binds to cargo through its light chains. In this issue Glater et al. (p. 545) demonstrate a new type of linkage through the adapter protein, milton, and the mitochondrial membrane GTPase, miro. This is an important result because it represents a new mechanism of cargo binding and because miro's ability to bind GTP and calcium suggests that it is involved in the regulation of mitochondrial transport.

Original languageEnglish (US)
Pages (from-to)459-461
Number of pages3
JournalJournal of Cell Biology
Volume173
Issue number4
DOIs
StatePublished - May 22 2006

ASJC Scopus subject areas

  • Cell Biology

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