TY - JOUR
T1 - Parafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography
AU - Onishi, Alex C.
AU - Treister, Alison D.
AU - Nesper, Peter L.
AU - Fawzi, Amani A.
AU - Anchala, Anupama R.
N1 - Funding Information:
This work was supported by an unrestricted grant to Northwestern University from Research to Prevent Blindness (New York, NY). OptoVue, Inc provided research instrument support to Northwestern University. The sponsor or funding organizations had no role in the design or conduct of this research or the decision to submit for publication.
Funding Information:
We would like to acknowledge Research to Prevent Blindness (New York, NY) which provided an unrestricted grant to Northwestern University. We would also like to acknowledge OptoVue, Inc which provided research instrument support to Northwestern University. This work was supported by an unrestricted grant to Northwestern University from Research to Prevent Blindness (New York, NY). OptoVue, Inc provided research instrument support to Northwestern University. The sponsor or funding organizations had no role in the design or conduct of this research or the decision to submit for publication.
Publisher Copyright:
© 2019 Onishi et al.
PY - 2019
Y1 - 2019
N2 - Purpose: To evaluate parafoveal and peripapillary perfusion in healthy, glaucoma suspect, normal-tension glaucoma, and primary open-angle glaucoma subjects. Patients and methods: This was a retrospective cross-sectional study with optical coherence tomography angiography imaging with RTVue XR Avanti (Optovue, Inc., Fremont, CA) of 56 eyes (14 healthy, 14 glaucoma suspect, 16 normal-tension glaucoma, and 12 primary open-angle glaucoma) at a tertiary academic referral center. Parafoveal and peripapillary superficial vessel density and parafoveal superficial retinal thickness were the main parameters of interest. Area under receiver operating characteristic curves were calculated. Results: There were significant decreases in parafoveal superficial vessel density in primary open-angle (40.06±4.54%, P<0.001) and normal-tension glaucoma (42.82±5.16%, P=0.010) but not suspect eyes (45.72±4.37%, P=0.916) compared to healthy eyes (48.10±2.82%). Similarly, decreases were observed in parafoveal inner retinal thickness in primary openangle (83.19±14.29 µm, P<0.001) and normal-tension glaucoma eyes (94.97±12.44 µm, P=0.035), but not suspect eyes (99.93±9.00 µm, P=0.648), compared to healthy controls (107.00±9.55 µm). Only primary open-angle glaucoma eyes displayed significant changes in peripapillary vessel density (37.63±7.19%) compared to healthy controls (49.12±2.80%, P<0.001). Further statistical adjustment for sex and age revealed a significant decrease in parafoveal vessel density in suspects relative to controls (P=0.039). Diagnostic accuracy of parafoveal vessel density was high with an area under the curve of 0.833±0.073 for normaltension glaucoma and 0.946±0.049 for primary open-angle glaucoma. Conclusion: Parafoveal vessel density was significantly reduced in glaucomatous eyes, with good diagnostic accuracy. These findings provide further evidence that these changes may be useful in the diagnosis and monitoring of disease in glaucoma patients.
AB - Purpose: To evaluate parafoveal and peripapillary perfusion in healthy, glaucoma suspect, normal-tension glaucoma, and primary open-angle glaucoma subjects. Patients and methods: This was a retrospective cross-sectional study with optical coherence tomography angiography imaging with RTVue XR Avanti (Optovue, Inc., Fremont, CA) of 56 eyes (14 healthy, 14 glaucoma suspect, 16 normal-tension glaucoma, and 12 primary open-angle glaucoma) at a tertiary academic referral center. Parafoveal and peripapillary superficial vessel density and parafoveal superficial retinal thickness were the main parameters of interest. Area under receiver operating characteristic curves were calculated. Results: There were significant decreases in parafoveal superficial vessel density in primary open-angle (40.06±4.54%, P<0.001) and normal-tension glaucoma (42.82±5.16%, P=0.010) but not suspect eyes (45.72±4.37%, P=0.916) compared to healthy eyes (48.10±2.82%). Similarly, decreases were observed in parafoveal inner retinal thickness in primary openangle (83.19±14.29 µm, P<0.001) and normal-tension glaucoma eyes (94.97±12.44 µm, P=0.035), but not suspect eyes (99.93±9.00 µm, P=0.648), compared to healthy controls (107.00±9.55 µm). Only primary open-angle glaucoma eyes displayed significant changes in peripapillary vessel density (37.63±7.19%) compared to healthy controls (49.12±2.80%, P<0.001). Further statistical adjustment for sex and age revealed a significant decrease in parafoveal vessel density in suspects relative to controls (P=0.039). Diagnostic accuracy of parafoveal vessel density was high with an area under the curve of 0.833±0.073 for normaltension glaucoma and 0.946±0.049 for primary open-angle glaucoma. Conclusion: Parafoveal vessel density was significantly reduced in glaucomatous eyes, with good diagnostic accuracy. These findings provide further evidence that these changes may be useful in the diagnosis and monitoring of disease in glaucoma patients.
KW - High-tension glaucoma
KW - Low-tension glaucoma
KW - Macular vessel density
KW - Retinal imaging
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U2 - 10.2147/OPTH.S206288
DO - 10.2147/OPTH.S206288
M3 - Article
C2 - 31579266
AN - SCOPUS:85073777312
SN - 1177-5467
VL - 13
SP - 1935
EP - 1945
JO - Clinical Ophthalmology
JF - Clinical Ophthalmology
ER -