Parallel detection of nucleic acids using an electronic chip

Prostate cancer is the most commonly diagnosed among North American men. The recent of altered genes that play an underlying role prostate cancer development has made the specific detection of nucleic acids especially . Multiplexed detection using electronic would permit sensitive, reliable, fast and identification of molecular biomarkers in settings. This would improve early diagnosis, would provide a route towards prognosis and new possibilities. Here we report for the first the development of a novel chip-based, array of nano-textured microelectrodes (NMEs) that can be used in automated detection of aof prostate cancer-related gene fusions in samples. The attomolar sensitivity along with unique multiplexing capability of this system make superior to the previously reported electrochemical nucleic acids sensors.