@article{e14f8e618faa4322914cb340eca99bf2,
title = "Parallel synthesis and spectroscopic analysis of a collection of heterocycles based on the diazabenz[e]aceanthrylene core structure",
abstract = "A practical strategy for the synthesis of diazabenz[e]aceanthrylene-based heterocycles is reported. The key step in this approach is a microwave-assisted condensation and cyclisation reaction between an anthranilic acid derivative and a 2′-carbomethoxy substituted N-aryl lactam. The scope of the reaction has been explored as a function of both the nature and position of substituents in both components and variations in lactam ring size. Interesting structural and spectroscopic variations observed across the compound collection are described and explored using NMR, X-ray crystallography and computational techniques.",
keywords = "Computational analysis, Heterocycles, Microwave, Variable temperature NMR analysis, Zipper reaction",
author = "Jones, {Alan M.} and Tomas Lebl and Stephen Patterson and {van Mourik}, Tanja and Fr{\"u}chtl, {Herbert A.} and Douglas Philp and Slawin, {Alexandra M.Z.} and Westwood, {Nicholas J.}",
note = "Funding Information: We would like to thank The Royal Society (University Research Fellowships to N.J.W. and T.v.M.), the BBSRC (A.M.J.), the Wellcome Trust (S.P.) and The University of St Andrews for funding. We would also like to thank Dr. Grace Vanier (CEM Labs, NC, USA) for photographic analysis of the microwave reactions. Mrs. M. H. Smith, Dr. C. Botting and Mrs. C. E. R. Horsburgh are kindly acknowledged for performing and assisting with NMR and MS analyses. We acknowledge EaStCHEM for computational support via the EaStCHEM Research Computing Facility ( http://www.eastchem.ac.uk/rcf ). ",
year = "2009",
month = jan,
day = "10",
doi = "10.1016/j.tet.2008.10.049",
language = "English (US)",
volume = "65",
pages = "563--578",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Ltd",
number = "2",
}