Parallel transport in diffeomorphisms distinguishes the time-dependent pattern of hippocampal surface deformation due to healthy aging and the dementia of the Alzheimer's type

Anqi Qiu*, Laurent Younes, Michael I. Miller, John G. Csernansky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Hippocampal surface structure was assessed at twice 2 years apart in 26 nondemented subjects (CDR 0), in 18 subjects with early dementia of Alzheimer type (DAT, CDR 0.5), and in 9 subjects who converted from the nondemented (CDR 0) to the demented (CDR 0.5) state using magnetic resonance (MR) imaging. We used parallel transport in diffeomorphisms under the large deformation diffeomorphic metric mapping framework to translate within-subject deformation of the hippocampal surface as represented in the MR images between the two time points in a global template coordinate system. We then performed hypothesis testing on the longitudinal variation of hippocampal shape in the global template. Both subjects with early DAT and converters showed greater rates of hippocampal deformation across time than nondemented controls within every subfield of the hippocampus. In a random field analysis, inward surface deformation across time occurred in a non-uniform manner across the hippocampal surface in subjects with early DAT relative to the nondemented controls. Also, compared to the controls, the lateral aspect of the left hippocampal tail showed inward surface deformation in the converters. Using surface deformation patterns as features in a linear discriminant analysis, we were able to respectively distinguish converters and patients with early DAT from healthy nondemented controls at classification rates of 0.77 and 0.87, which were obtained in the same training set using the leave-one-out cross validation approach.

Original languageEnglish (US)
Pages (from-to)68-76
Number of pages9
JournalNeuroimage
Volume40
Issue number1
DOIs
StatePublished - Mar 1 2008

Funding

The authors would like to thank Dr. Lei Wang from Washington University at St. Louis for the hippocampus structure delineation. The authors would also like to thank Dr. John C. Morris for reading the manuscript. The work reported here was supported by grants: NIH R01 MH064838, NIH RO1 060883, NIH RO1 AG 025824, NIH R01 EB00975, NIH P50 MH071616, NIH P41 RR15241, NIH P01 AG03991, NIH P50 AG05681, NSF DMS 0456253, and National University of Singapore start-up grant R-397-000-058-133.

Keywords

  • Alzheimer's disease
  • Hippocampus
  • LDDMM
  • Parallel transport
  • Shape analysis

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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