Paramagnetic Mn8Fe4- co-Polystyrene Nanobeads as a Potential T1-T2Multimodal Magnetic Resonance Imaging Contrast Agent with in Vivo Studies

Vidumin Dahanayake, Trevor Lyons, Brendan Kerwin, Olga Rodriguez, Christopher Albanese, Erika Parasido, Yichien Lee, Edward Van Keuren, Luxi Li, Evan Maxey, Tatjana Paunesku, Gayle Woloschak, Sarah L. Stoll*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In developing a cluster-nanocarrier design, as a magnetic resonance imaging contrast agent, we have investigated the enhanced relaxivity of a manganese and iron-oxo cluster grafted within a porous polystyrene nanobead with increased relaxivity due to a higher surface area. The synthesis of the cluster-nanocarrier for the cluster Mn8Fe4O12(O2CC6H4CH=CH2)16(H2O)4, cross-linked with polystyrene (the nanocarrier), under miniemulsion conditions is described. By including a branched hydrophobe, iso-octane, the resulting nanobeads are porous and ∼70 nm in diameter. The increased surface area of the nanobeads compared to nonporous nanobeads leads to an enhancement in relaxivity; r1 increases from 3.8 to 5.2 ± 0.1 mM-1 s-1, and r2 increases from 11.9 to 50.1 ± 4.8 mM-1 s-1, at 9.4 teslas, strengthening the potential for T1 and T2 imaging. Several metrics were used to assess stability, and the porosity produced no reduction in metal stability. Synchrotron X-ray fluorescence microscopy was used to demonstrate that the nanobeads remain intact in vivo. In depth, physicochemical characteristics were determined, including extensive pharmacokinetics, in vivo imaging, and systemic biodistribution analysis.

Original languageEnglish (US)
Pages (from-to)39042-39054
Number of pages13
JournalACS Applied Materials and Interfaces
Volume13
Issue number33
DOIs
StatePublished - Aug 25 2021

Keywords

  • MRI contrast agent
  • XRF microscopy
  • biocompatible
  • cluster-nanocarrier
  • miniemulsion

ASJC Scopus subject areas

  • Materials Science(all)

Fingerprint

Dive into the research topics of 'Paramagnetic Mn8Fe4- co-Polystyrene Nanobeads as a Potential T1-T2Multimodal Magnetic Resonance Imaging Contrast Agent with in Vivo Studies'. Together they form a unique fingerprint.

Cite this