Paramyxovirus disruption of interferon signal transduction: STATus report

Aparna Ramachandran, Curt M. Horvath

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

RNA viruses in the paramyxovirus family have evolved a number of strategies to escape host cell surveillance and antiviral responses. One mechanism exploited by a number of viruses in this family is direct targeting of cytokine-inducible transcription regulators in the STAT family. Diverse members of this large virus family effectively suppress STAT signaling by the actions of their V proteins, or the related proteins derived from alternate viral mRNAs. These viral proteins have distinct means of targeting STATs, resulting in a variety of negative effects on STATs and their signal transduction. Recent developments in understanding STAT targeting will be reviewed.

Original languageEnglish (US)
Pages (from-to)531-537
Number of pages7
JournalJournal of Interferon and Cytokine Research
Volume29
Issue number9
DOIs
StatePublished - Sep 1 2009

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology

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