Paraneoplastic nerve hyperexcitability

Jennifer A. Liebenthal, Kourosh Rezania, Martin K. Nicholas, Rimas V. Lukas*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Objectives: To provide an overview of paraneoplastic nerve hyperexcitability syndromes. Methods: An extensive review of the literature on nerve hyperexcitability was performed. Particular attention was paid to Isaacs’ syndrome and Morvan’s syndrome, as well as their relationship to neoplasia. Results: An overview of the history, clinical manifestations (including neurophysiologic findings), pathophysiology, and management is presented. Clinical differences between the exclusively peripheral nervous system involving Isaacs’ syndrome and Morvan’s syndrome, which also involves the central nervous system (CNS) are detailed. The role of immune-mediated dysfunction of specific components of the voltage-gated potassium channel (VGKC) complex in the pathophysiology of these syndromes is explained. Finally, the limited data on management of these syndromes, including the use of antiepileptic and immunomodulatory therapies are discussed. Conclusion: Nerve hyperexcitability syndrome represents a spectrum of neuroimmunologic diseases, which are often paraneoplastic in etiology.

Original languageEnglish
Pages (from-to)553-559
Number of pages7
JournalNeurological Research
Issue number6
StatePublished - May 1 2015


  • Isaacs’ syndrome
  • Morvan’s syndrome
  • Myokymia
  • Nervous system
  • Paraneoplastic syndromes

ASJC Scopus subject areas

  • Medicine(all)
  • Neurology
  • Clinical Neurology

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