Parathyroid hormone-stimulated calcium absorption in cTAL from vitamin D-deficient rabbits

J. E. Bourdeau, C. B. Langman, R. Bouillon, A. L. Theisen

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Cortical thick ascending limbs of Henle's loop were dissected from the kidneys of chronically vitamin D-deficient or -replete rabbits and perfused in vitro. Unidirectional transepithelial calcium fluxes from lumen to bath were measured with 45Ca. The tubules were bathed in a solution containing 150 mM sodium and perfused with a solution containing 60 mM sodium to simulate conditions in the cortical thick ascending limb in vivo. Transepithelial voltages were equal across tubules from vitamin D-deficient and -replete rabbits. Likewise, baseline and parathyroid hormone-stimulated calcium fluxes were the same in tubules from the two groups. Because calcidiol and calcitriol were undetectable in the serum of the vitamin D-deficient rabbits, we suggest that neither of these endogenous vitamin D metabolites is essential in the regulation of calcium absorption in this portion of the rabbit nephron.

Original languageEnglish (US)
Pages (from-to)913-917
Number of pages5
JournalKidney international
Volume31
Issue number4
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Nephrology

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