Parathyromimetic effects of the ionophore, A23187, on bone cells and organ cultures

R. Dziak*, P. Stern

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

The ionophore, A23187, increased calcium uptake by isolated bone cells in a manner similar to parathyroid hormone. Cellular cyclic AMP was increased after a 30 minute incubation with 0.3 μg/ml A23187; at higher ionophore concentrations (1.0 - 10.0 μg/ml) cyclic AMP was decreased. Resorption of cultured fetal rat long bone also exhibited a biphasic response to the ionophore. With doses of 0.1 - 1.0 μg/ml resorption was increased; higher doses decreased resorption. The data suggest that calcium may be the primary initiator of the action of parathyroid hormone on bone.

Original languageEnglish (US)
Pages (from-to)1343-1349
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume65
Issue number4
DOIs
StatePublished - Aug 18 1975

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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