TY - JOUR
T1 - Parental Rheumatoid Arthritis and Autism Spectrum Disorders in Offspring
T2 - A Danish Nationwide Cohort Study
AU - Rom, Ane Lilleøre
AU - Wu, Chun Sen
AU - Olsen, Jørn
AU - Jawaheer, Damini
AU - Hetland, Merete Lund
AU - Mørch, Lina Steinrud
N1 - Funding Information:
We used data from various Danish national registries, which were linked by the unique identification number assigned to all citizens in Denmark. Through the Danish Medical Birth Registry, we established a nationwide cohort of all children (singletons) born alive in Denmark from 1977 to 2008, a total of 1,917,723 children. The study population and data sources are further described in a previous article. 18 The study was approved by the Danish Data Protection Agency (Jr. no. 2016-41-4737).
Publisher Copyright:
© 2017 American Academy of Child and Adolescent Psychiatry
PY - 2018/1
Y1 - 2018/1
N2 - Objective Maternal rheumatoid arthritis (RA) has been associated with an increased risk of autism spectrum disorder (ASD) in the offspring. We assessed the potential influence of both maternal and paternal RA on the risk of ASD in offspring to disentangle the influence of genetic inheritance from other conditions potentially leading to fetal programming. Method The nationwide cohort study included all children born alive from 1977 to 2008 in Denmark (N = 1,917,723). Cox regression models were used to calculate hazard rate ratios (HR) of ASD in offspring exposed to maternal or paternal RA, compared to unexposed children. Results Maternal RA was associated with an approximately 30% increased risk of ASD in the offspring (HR = 1.31 and 95% CI = 1.06−1.63). Also, paternal RA seemed to increase the risk of ASD by approximately 30% (HR = 1.33, 95% CI = 0.97−1.82). Conclusion Our findings suggest maternal as well as paternal RA to be associated with an increased risk of ASD in the offspring, indicating that genetic factors associated with RA may also play a role in the etiology of ASD in children of parents with RA.
AB - Objective Maternal rheumatoid arthritis (RA) has been associated with an increased risk of autism spectrum disorder (ASD) in the offspring. We assessed the potential influence of both maternal and paternal RA on the risk of ASD in offspring to disentangle the influence of genetic inheritance from other conditions potentially leading to fetal programming. Method The nationwide cohort study included all children born alive from 1977 to 2008 in Denmark (N = 1,917,723). Cox regression models were used to calculate hazard rate ratios (HR) of ASD in offspring exposed to maternal or paternal RA, compared to unexposed children. Results Maternal RA was associated with an approximately 30% increased risk of ASD in the offspring (HR = 1.31 and 95% CI = 1.06−1.63). Also, paternal RA seemed to increase the risk of ASD by approximately 30% (HR = 1.33, 95% CI = 0.97−1.82). Conclusion Our findings suggest maternal as well as paternal RA to be associated with an increased risk of ASD in the offspring, indicating that genetic factors associated with RA may also play a role in the etiology of ASD in children of parents with RA.
KW - autism spectrum disorders
KW - maternal history
KW - offspring
KW - parental history
KW - rheumatoid arthritis
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U2 - 10.1016/j.jaac.2017.10.002
DO - 10.1016/j.jaac.2017.10.002
M3 - Article
C2 - 29301665
AN - SCOPUS:85039971620
VL - 57
SP - 28-32.e1
JO - Journal of the American Academy of Child Psychiatry
JF - Journal of the American Academy of Child Psychiatry
SN - 0890-8567
IS - 1
ER -
