TY - JOUR
T1 - Parental Rheumatoid Arthritis, Child Mortality, and Case Fatality
T2 - A Nationwide Cohort Study
AU - Rom, Ane L.
AU - Wu, Chun S.
AU - Olsen, Jørn
AU - Jawaheer, Damini
AU - Hetland, Merete L.
AU - Ottesen, Bent
AU - Mørch, Lina S.
N1 - Funding Information:
Dr. Rom's work was supported by the NIH (grant 5‐R21‐AR‐059931‐02), the Danish Council for Independent Research, and the Augustinus Foundation.
Publisher Copyright:
© 2016, American College of Rheumatology
PY - 2017/6
Y1 - 2017/6
N2 - Objective: We have previously reported increased long-term morbidity in children of parents with rheumatoid arthritis (RA). Here we assess child mortality and case fatality in the same cohort. Methods: All singletons born in Denmark from 1977 to 2008 were identified through linkage of Danish national registries. Cox proportional hazards models were used to calculate hazard ratios (HRs) of death from all causes among children exposed to parental RA, compared to unexposed children. Risk of death after infection or respiratory diseases was also assessed for children below the age of 5 years. Results: This study followed 1,917,723 newborns for an average of 16 years. Of these, 13,556 were exposed to maternal RA and 6,330 to paternal RA. Overall mortality rates in children exposed to maternal or paternal RA did not differ from those in unexposed children (HR 0.98 [95% confidence interval (95% CI) 0.84–1.15] and 1.08 [95% CI 0.86–1.36], respectively), nor did the risk of death below the ages of 5 years, 3 years, or 1 year. In the group of children below the age of 5 years, 6,106 children of parents with RA were diagnosed with respiratory diseases and 3,320 with infectious diseases. The case fatality rate in children with these diseases was not significantly higher than in unexposed children (HR 1.11 [95% CI 0.74–1.66] and 0.84 [95% CI 0.52–1.35], respectively). Conclusion: Children of parents with RA had similar mortality rates as other children, as well as after diagnoses of respiratory or infectious diseases.
AB - Objective: We have previously reported increased long-term morbidity in children of parents with rheumatoid arthritis (RA). Here we assess child mortality and case fatality in the same cohort. Methods: All singletons born in Denmark from 1977 to 2008 were identified through linkage of Danish national registries. Cox proportional hazards models were used to calculate hazard ratios (HRs) of death from all causes among children exposed to parental RA, compared to unexposed children. Risk of death after infection or respiratory diseases was also assessed for children below the age of 5 years. Results: This study followed 1,917,723 newborns for an average of 16 years. Of these, 13,556 were exposed to maternal RA and 6,330 to paternal RA. Overall mortality rates in children exposed to maternal or paternal RA did not differ from those in unexposed children (HR 0.98 [95% confidence interval (95% CI) 0.84–1.15] and 1.08 [95% CI 0.86–1.36], respectively), nor did the risk of death below the ages of 5 years, 3 years, or 1 year. In the group of children below the age of 5 years, 6,106 children of parents with RA were diagnosed with respiratory diseases and 3,320 with infectious diseases. The case fatality rate in children with these diseases was not significantly higher than in unexposed children (HR 1.11 [95% CI 0.74–1.66] and 0.84 [95% CI 0.52–1.35], respectively). Conclusion: Children of parents with RA had similar mortality rates as other children, as well as after diagnoses of respiratory or infectious diseases.
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U2 - 10.1002/acr.22991
DO - 10.1002/acr.22991
M3 - Article
C2 - 27390220
AN - SCOPUS:85019036318
SN - 2151-464X
VL - 69
SP - 933
EP - 937
JO - Arthritis and Rheumatism
JF - Arthritis and Rheumatism
IS - 6
ER -
