Parietal cell carcinoma of gastric cardia: Immunophenotype and ultrastructure

Guang Yu Yang, Jie Liao, Nicholas D. Cassai, Adam J. Smolka, Gurdip S. Sidhu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The case is reported of a clinically aggressive parietal cell carcinoma of the gastric cardia in a 67-year-old man. Histologically, the tumor was a poorly differentiated adenocarcinoma with a predominantly solid growth pattern, though with areas exhibiting glandular morphology and with extensive lymphatic invasion. The tumor cells had eosinophilic, finely granular cytoplasm, with focal Alcian blue-positive mucin in the gland lumens. Ultrastructural examination of the pleural metastasis and gastrectomy specimen demonstrated many mitochondria, tubulovesicular profiles of endoplasmic reticulum, and intracytoplasmic lumens, which resembled intracellular canaliculi of parietal cells. Immunohistochemically, there was positive staining of tumor cells for the parietal cell specific antibodies to H/K-ATPase and human milk fat globule-2 (HMFG-2).

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalUltrastructural Pathology
Issue number2
StatePublished - Mar 1 2003


  • Immunohistochemistry
  • Parietal cell carcinoma
  • Stomach
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology


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