Parkinson's Disease

Jennifer G Goldman*, S. Holden

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting about five million people worldwide and typically presenting around age 60. Its underlying cause is unknown, but complex interactions between genetic and environmental factors contribute. There is no cure for PD, but symptomatic treatments are available and research efforts are focused on neuroprotection and disease-modification. PD is recognized clinically by its motor features including slowness, stiffness, tremor, and gait problems. However, many non-motor features affecting mood, sleep, cognition, and autonomic function also occur. In this article, we will discuss the pathophysiology of PD, its symptoms, general treatment approaches, and future research directions.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Mental Health
Subtitle of host publicationSecond Edition
PublisherElsevier Inc
Number of pages7
ISBN (Electronic)9780123970459
ISBN (Print)9780123977533
StatePublished - Jan 1 2016


  • Basal ganglia
  • Cognitive impairment
  • Depression
  • Dopamine
  • Lewy body
  • Movement disorders
  • Non-motor symptoms
  • Parkinson's disease
  • Parkinsonism
  • Psychosis

ASJC Scopus subject areas

  • Psychology(all)

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