Partial correlation investigation on the default mode network involved in acupuncture: An fMRI study

Peng Liu; Yi Zhang; Guangyu Zhou; Kai Yuan; Wei Qin; Lu Zhuo; Jimin Liang; Peng Chen; Jianping Dai; Yijun Liu; Jie Tian

doi:10.1016/j.neulet.2009.07.015

Partial correlation investigation on the default mode network involved in acupuncture: An fMRI study

Peng Liu, Yi Zhang, Guangyu Zhou, Kai Yuan, Wei Qin, Lu Zhuo, Jimin Liang, Peng Chen, Jianping Dai, Yijun Liu, Jie Tian^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Certain clinical reports and researches have shown that acupuncture effects can sustain a period during the post-stimulation state, and modulate the default mode network (DMN). In this study, partial correlation approach was utilized to investigate whether or not electro-acupuncture stimulation (EAS) at the three acupoints (GB37 (Guangming), BL60 (Kunlun) and KI8 (Jiaoxin)) and one sham point on the left leg modulated the DMN and how to change the intrinsic connectivity of the DMN. The results indicated that DMN could be modulated after EAS, and there existed different modulation patterns of the four points. Meanwhile, we found that the posterior cingulate cortex and precuneus (PCC/pC) strongly interacted with other nodes during the pre- and post-stimulation states. The correlation was interrupted between the PCC/pC and anterior cingulate cortex (ACC). The orbital prefrontal cortex (OFC) negatively interacted with the left medial temporal cortex (lMTC) at the acupoints. We suggested that the distinct modulation patterns to the DMN attributed to the different effects evoked by the three acupoints and one sham point.

Original language	English (US)
Pages (from-to)	183-187
Number of pages	5
Journal	Neuroscience Letters
Volume	462
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2009.07.015
State	Published - Sep 25 2009
Externally published	Yes

Funding

This study is supported by Changjiang Scholars and Innovative Research Team in University (PCSIRT) under Grant No. IRT0645, Chair Professors of Cheung Kong Scholars Program, CAS Hundred Talents Program, the Joint Research Fund for Overseas Chinese Young Scholars under Grant No. 30528027, the National Natural Science Foundation of China under Grant Nos. 30873462, 90209008, 30870685, 30672690, 30600151, 60532050, 60621001, the Beijing Natural Science Fund under Grant No. 4071003, the Project for the National Key Basic Research and Development Program (973) under Grant No. 2006CB705700, and 863 program under Grant No. 2008AA01Z411.

Keywords

Acupuncture
Partial correlation
The default mode network
fMRI

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2009.07.015

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title = "Partial correlation investigation on the default mode network involved in acupuncture: An fMRI study",

abstract = "Certain clinical reports and researches have shown that acupuncture effects can sustain a period during the post-stimulation state, and modulate the default mode network (DMN). In this study, partial correlation approach was utilized to investigate whether or not electro-acupuncture stimulation (EAS) at the three acupoints (GB37 (Guangming), BL60 (Kunlun) and KI8 (Jiaoxin)) and one sham point on the left leg modulated the DMN and how to change the intrinsic connectivity of the DMN. The results indicated that DMN could be modulated after EAS, and there existed different modulation patterns of the four points. Meanwhile, we found that the posterior cingulate cortex and precuneus (PCC/pC) strongly interacted with other nodes during the pre- and post-stimulation states. The correlation was interrupted between the PCC/pC and anterior cingulate cortex (ACC). The orbital prefrontal cortex (OFC) negatively interacted with the left medial temporal cortex (lMTC) at the acupoints. We suggested that the distinct modulation patterns to the DMN attributed to the different effects evoked by the three acupoints and one sham point.",

keywords = "Acupuncture, Partial correlation, The default mode network, fMRI",

author = "Peng Liu and Yi Zhang and Guangyu Zhou and Kai Yuan and Wei Qin and Lu Zhuo and Jimin Liang and Peng Chen and Jianping Dai and Yijun Liu and Jie Tian",

note = "Funding Information: This study is supported by Changjiang Scholars and Innovative Research Team in University (PCSIRT) under Grant No. IRT0645, Chair Professors of Cheung Kong Scholars Program, CAS Hundred Talents Program, the Joint Research Fund for Overseas Chinese Young Scholars under Grant No. 30528027, the National Natural Science Foundation of China under Grant Nos. 30873462, 90209008, 30870685, 30672690, 30600151, 60532050, 60621001, the Beijing Natural Science Fund under Grant No. 4071003, the Project for the National Key Basic Research and Development Program (973) under Grant No. 2006CB705700, and 863 program under Grant No. 2008AA01Z411.",

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language = "English (US)",

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T1 - Partial correlation investigation on the default mode network involved in acupuncture

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AU - Liu, Peng

AU - Zhang, Yi

AU - Zhou, Guangyu

AU - Yuan, Kai

AU - Qin, Wei

AU - Zhuo, Lu

AU - Liang, Jimin

AU - Chen, Peng

AU - Dai, Jianping

AU - Liu, Yijun

AU - Tian, Jie

N1 - Funding Information: This study is supported by Changjiang Scholars and Innovative Research Team in University (PCSIRT) under Grant No. IRT0645, Chair Professors of Cheung Kong Scholars Program, CAS Hundred Talents Program, the Joint Research Fund for Overseas Chinese Young Scholars under Grant No. 30528027, the National Natural Science Foundation of China under Grant Nos. 30873462, 90209008, 30870685, 30672690, 30600151, 60532050, 60621001, the Beijing Natural Science Fund under Grant No. 4071003, the Project for the National Key Basic Research and Development Program (973) under Grant No. 2006CB705700, and 863 program under Grant No. 2008AA01Z411.

PY - 2009/9/25

Y1 - 2009/9/25

N2 - Certain clinical reports and researches have shown that acupuncture effects can sustain a period during the post-stimulation state, and modulate the default mode network (DMN). In this study, partial correlation approach was utilized to investigate whether or not electro-acupuncture stimulation (EAS) at the three acupoints (GB37 (Guangming), BL60 (Kunlun) and KI8 (Jiaoxin)) and one sham point on the left leg modulated the DMN and how to change the intrinsic connectivity of the DMN. The results indicated that DMN could be modulated after EAS, and there existed different modulation patterns of the four points. Meanwhile, we found that the posterior cingulate cortex and precuneus (PCC/pC) strongly interacted with other nodes during the pre- and post-stimulation states. The correlation was interrupted between the PCC/pC and anterior cingulate cortex (ACC). The orbital prefrontal cortex (OFC) negatively interacted with the left medial temporal cortex (lMTC) at the acupoints. We suggested that the distinct modulation patterns to the DMN attributed to the different effects evoked by the three acupoints and one sham point.

AB - Certain clinical reports and researches have shown that acupuncture effects can sustain a period during the post-stimulation state, and modulate the default mode network (DMN). In this study, partial correlation approach was utilized to investigate whether or not electro-acupuncture stimulation (EAS) at the three acupoints (GB37 (Guangming), BL60 (Kunlun) and KI8 (Jiaoxin)) and one sham point on the left leg modulated the DMN and how to change the intrinsic connectivity of the DMN. The results indicated that DMN could be modulated after EAS, and there existed different modulation patterns of the four points. Meanwhile, we found that the posterior cingulate cortex and precuneus (PCC/pC) strongly interacted with other nodes during the pre- and post-stimulation states. The correlation was interrupted between the PCC/pC and anterior cingulate cortex (ACC). The orbital prefrontal cortex (OFC) negatively interacted with the left medial temporal cortex (lMTC) at the acupoints. We suggested that the distinct modulation patterns to the DMN attributed to the different effects evoked by the three acupoints and one sham point.

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Partial correlation investigation on the default mode network involved in acupuncture: An fMRI study

Abstract

Funding

Keywords

ASJC Scopus subject areas

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