Partial wave spectroscopic microscopy: Detecting alterations in cell nanoarchitecture in early carcinogenesis

Vadim Backman*, Robert H. Lurie

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Understanding cell functioning at the nanoscale has been hampered in part by the diffraction limited resolution of optical microscopy. We developed an optical microscopic spectroscopy technique, partial wave spectroscopic (PWS) microscopy, that is capable of quantifying statistical properties of cell structure at the nanoscale. Our animal and human studies demonstrated that alterations in the nanoscale cell architecture is one of the earliest events in carcinogenesis and precedes any other known morphological changes at large length scales (i.e. microarchitecture). This appears to be a general event in carcinogenesis, which is supported by our data in five types of cancer: colon, pancreatic, lung, esophageal and ovarian cancers.

Original languageEnglish (US)
Title of host publicationIEEE Photonic Society 24th Annual Meeting, PHO 2011
Number of pages1
DOIs
StatePublished - Dec 1 2011
Event24th Annual Meeting on IEEE Photonic Society, PHO 2011 - Arlington, VA, United States
Duration: Oct 9 2011Oct 13 2011

Publication series

NameIEEE Photonic Society 24th Annual Meeting, PHO 2011

Other

Other24th Annual Meeting on IEEE Photonic Society, PHO 2011
Country/TerritoryUnited States
CityArlington, VA
Period10/9/1110/13/11

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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