Partial wave spectroscopic microscopy: Detecting alterations in cell nanoarchitecture in early carcinogenesis

Vadim Backman; Robert H. Lurie

doi:10.1109/PHO.2011.6110800

Partial wave spectroscopic microscopy: Detecting alterations in cell nanoarchitecture in early carcinogenesis

Vadim Backman^*, Robert H. Lurie

^*Corresponding author for this work

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Understanding cell functioning at the nanoscale has been hampered in part by the diffraction limited resolution of optical microscopy. We developed an optical microscopic spectroscopy technique, partial wave spectroscopic (PWS) microscopy, that is capable of quantifying statistical properties of cell structure at the nanoscale. Our animal and human studies demonstrated that alterations in the nanoscale cell architecture is one of the earliest events in carcinogenesis and precedes any other known morphological changes at large length scales (i.e. microarchitecture). This appears to be a general event in carcinogenesis, which is supported by our data in five types of cancer: colon, pancreatic, lung, esophageal and ovarian cancers.

Original language	English (US)
Title of host publication	IEEE Photonic Society 24th Annual Meeting, PHO 2011
Number of pages	1
DOIs	https://doi.org/10.1109/PHO.2011.6110800
State	Published - Dec 1 2011
Event	24th Annual Meeting on IEEE Photonic Society, PHO 2011 - Arlington, VA, United States Duration: Oct 9 2011 → Oct 13 2011

Publication series

Name	IEEE Photonic Society 24th Annual Meeting, PHO 2011

Other

Other	24th Annual Meeting on IEEE Photonic Society, PHO 2011
Country/Territory	United States
City	Arlington, VA
Period	10/9/11 → 10/13/11

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/PHO.2011.6110800

Cite this

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title = "Partial wave spectroscopic microscopy: Detecting alterations in cell nanoarchitecture in early carcinogenesis",

abstract = "Understanding cell functioning at the nanoscale has been hampered in part by the diffraction limited resolution of optical microscopy. We developed an optical microscopic spectroscopy technique, partial wave spectroscopic (PWS) microscopy, that is capable of quantifying statistical properties of cell structure at the nanoscale. Our animal and human studies demonstrated that alterations in the nanoscale cell architecture is one of the earliest events in carcinogenesis and precedes any other known morphological changes at large length scales (i.e. microarchitecture). This appears to be a general event in carcinogenesis, which is supported by our data in five types of cancer: colon, pancreatic, lung, esophageal and ovarian cancers.",

author = "Vadim Backman and Lurie, {Robert H.}",

year = "2011",

month = dec,

day = "1",

doi = "10.1109/PHO.2011.6110800",

language = "English (US)",

isbn = "9781424489404",

series = "IEEE Photonic Society 24th Annual Meeting, PHO 2011",

booktitle = "IEEE Photonic Society 24th Annual Meeting, PHO 2011",

note = "24th Annual Meeting on IEEE Photonic Society, PHO 2011 ; Conference date: 09-10-2011 Through 13-10-2011",

}

Backman, V & Lurie, RH 2011, Partial wave spectroscopic microscopy: Detecting alterations in cell nanoarchitecture in early carcinogenesis. in IEEE Photonic Society 24th Annual Meeting, PHO 2011., 6110800, IEEE Photonic Society 24th Annual Meeting, PHO 2011, 24th Annual Meeting on IEEE Photonic Society, PHO 2011, Arlington, VA, United States, 10/9/11. https://doi.org/10.1109/PHO.2011.6110800

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T1 - Partial wave spectroscopic microscopy

T2 - 24th Annual Meeting on IEEE Photonic Society, PHO 2011

AU - Backman, Vadim

AU - Lurie, Robert H.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Understanding cell functioning at the nanoscale has been hampered in part by the diffraction limited resolution of optical microscopy. We developed an optical microscopic spectroscopy technique, partial wave spectroscopic (PWS) microscopy, that is capable of quantifying statistical properties of cell structure at the nanoscale. Our animal and human studies demonstrated that alterations in the nanoscale cell architecture is one of the earliest events in carcinogenesis and precedes any other known morphological changes at large length scales (i.e. microarchitecture). This appears to be a general event in carcinogenesis, which is supported by our data in five types of cancer: colon, pancreatic, lung, esophageal and ovarian cancers.

AB - Understanding cell functioning at the nanoscale has been hampered in part by the diffraction limited resolution of optical microscopy. We developed an optical microscopic spectroscopy technique, partial wave spectroscopic (PWS) microscopy, that is capable of quantifying statistical properties of cell structure at the nanoscale. Our animal and human studies demonstrated that alterations in the nanoscale cell architecture is one of the earliest events in carcinogenesis and precedes any other known morphological changes at large length scales (i.e. microarchitecture). This appears to be a general event in carcinogenesis, which is supported by our data in five types of cancer: colon, pancreatic, lung, esophageal and ovarian cancers.

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U2 - 10.1109/PHO.2011.6110800

DO - 10.1109/PHO.2011.6110800

M3 - Conference contribution

AN - SCOPUS:84856013942

SN - 9781424489404

T3 - IEEE Photonic Society 24th Annual Meeting, PHO 2011

BT - IEEE Photonic Society 24th Annual Meeting, PHO 2011

Y2 - 9 October 2011 through 13 October 2011

ER -

Partial wave spectroscopic microscopy: Detecting alterations in cell nanoarchitecture in early carcinogenesis

Abstract

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ASJC Scopus subject areas

UN SDGs

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